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Environmental fate & pathways

Biodegradation in water: screening tests

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Description of key information

Biodegradability was assessed in a guideline OECD 301D study (key study) as well as two additional supporting studies.

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In the key study, no biodegradation of the test compound was observed. In a supporting study, the amount of test compound biodegraded over 7, 15 and 28 days based on BOD was 7%, 7%, and 9%, respectively. Primary biodegradation (i.e. loss of parent compound) based on GC analysis was 18% over 28 days. 1-Nitropropane is not readily biodegradable. In the 1990 supporting study, 1- nitropropane was degraded by 5.6%, 29.8% and 45.1% after 5, 15, and 28 days, respectively in a similar OECD 301D closed bottle test. Therefore, the material was degraded, but did not degrade enough to be classified as readily biodegradable. In the 1987 supporting study, 50 ug/L radiolabeled test compound was added to 1000 mg/L activated sludge and the radiolabeled CO2 was collected in traps. The amount of material degraded to 14CO2 after 5 days was 20.2% and 26.4%, for an average of 23.3%. The results of the three biodegradation studies indicate that 1-nitropropane meets the criteria of inherent, primary biodegradability as described in the OECD guidelines.