Registration Dossier
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EC number: 941-267-1 | CAS number: 1445870-18-7
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
There are no studies available in which the toxicokinetic properties of the test substance were investigated. Assessment of absorption, metabolism and excretion based on single and repeated dose studies.
Chemistry
The test substance (molecular weight of 482 Da) is a yellowish liquid those water solubility (deionised water) is < 0.0004 mg/l. Based on individual solubilities in water and octanol the logPow is calculated to be > 9.4, measured by HPLC logPow is > 6.5. Examination of the vapour pressure was carried by effusion method, extrapolated to 25 ° VP is < 0.000001 hPa. In regard to the molecular structure of the substance and the poor solubility in water hydrolysis is not likely.
Absorption
In an acute oral and dermal toxicity study, rats were administered to the test substance. No mortalities or clinical signs of toxicity were observed at the limit dose of 2000 mg/kg bw, indicating primarily a very low level of oral and dermal toxicity. The NOAEL in male and female rats in an OECD 422 study is 150 mg/kg bw (in progress)
Based on a calculation according to the model of Fitzpatrick the substance is expected to be skin (moderately) permeable (Fitzpatrick, et al., 2004).
Metabolism
Single oral application of the test item to male and female rats did not provoke any effect. Mortality was not observed up to the highest dose level .
In progress
Excretion
In progress
Used references:
Fitzpatrick, D., et al. (2004). "Modelling skin permeability in risk assessment-the future." Chemosphere 55 (10): 1309-14.
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