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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Study period:
1973
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study according to internal BASF standards

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1973
Report date:
1973

Materials and methods

Principles of method if other than guideline:
BASF-Testing method
GLP compliance:
no

Test material

Constituent 1
Reference substance name:
Vat Indigo Sodium Salt
IUPAC Name:
Vat Indigo Sodium Salt
Details on test material:
- Name of test material (as cited in study report): Indigoküpe BASF 60% Körner
- Substance type: preparation
- Physical state: solid

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
no data

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
water
Details on exposure:
0.1% to 30% concentration in vehicle
Doses:
no data
No. of animals per sex per dose:
no data
Control animals:
no
Details on study design:
- Duration of observation period following administration: 7 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: yes
Statistics:
NA

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
ca. 30 mg/kg bw
Mortality:
no data
Clinical signs:
ataxia, dyspnea, tremor
Body weight:
no data
Gross pathology:
intraabdominal precipitation of TS

Applicant's summary and conclusion

Conclusions:
The intraperitoneal LD50 in the mouse is approximately 30 mg/kg bw. As the intraperitoneal LD50 of indigo powder proved to be approximately 8000 mg/kg bw, the significantly lower dermal LD50 of Indigoküpe 60% Körner is most likely due to the 5% alkali content.