2-[(1-amino-9,10-dihydro-4-hydroxy-9,10-dioxo-2-anthryl)oxy]ethyl phenyl carbonate

Vapour pressure

Link to relevant study record(s)

Reference

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2014-08-04

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

GLP compliance:

yes (incl. QA statement)

Type of method:

effusion method: by loss of weight or by trapping vaporisate

Key result

Test no.:

#1

Temp.:

20 °C

Vapour pressure:

<= 0 Pa

 The main tests showed, that below 200 °C no significant weight loss was observed. The vapour pressure cannot be determined with sufficient accuracy. The determination was repeated applying temperatures above 200 °C.

The regression curve for calibration is: The coefficient of correlation (r²) was 0.9981. Extrapolation of the curve to 20 °C and fitting this value in the regression curve, a vapour pressure of 4.65 × 10^-11 Pa was obtained (temperature program 200 °C to 250 °C, evaluation at 210 °C to 240 °C).

Conclusions:

The isothermal thermogravimetric effusion method was chosen for the determination of the vapour pressure of FAT 93504/B. The vapour pressure of the test item at 20 °C (293K) was: 4.65 × 10E-11 Pa (mean of three measurements).

Executive summary:

The vapour pressure of the test item was determined based on the procedures indicated by the following internationally accepted methods:

- OECD Guideline 104

- EU Method A.4

The purpose of the study was to determine the vapour pressure of the test item using the isothermal thermogravimetrical effusion method. The evaporation rates of the test item at elevated temperatures and ambient pressure were determined by monitoring the weight loss. The isothermal thermogravimetric effusion method was applied for the determination of the vapour pressure of FAT 93504/B. In tests at temperatures below 200 °C no significant weight loss was observed and the vapour pressure at 20 °C (293K) cannot be determined with sufficient accuracy. A value of the vapour pressure of the test item could only be determined using the data obtained above 200 °C. The vapour pressure of the test item at 20 °C (293K) was calculated to: 4.65 × 10-11 Pa (mean of three determinations). This study is classified acceptable and satisfies the guideline requirements for vapour pressure studies.

Description of key information

The vapour pressure of the test item at 20 °C (293K) was calculated to: 4.65 × 10^-11 Pa.

Key value for chemical safety assessment

Vapour pressure:

0 Pa

at the temperature of:

20 °C

Additional information

The isothermal thermogravimetric effusion method was applied for the determination of the vapour pressure of FAT 93504/B. The vapour pressure of the test item at 20 °C (293K) was calculated to: 4.65 × 10^-11 Pa (mean of three measurements). However, for the purpose of chemical afety assessment, it was considered to be 0.000001 Pa.