Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 412-300-2 | CAS number: 139504-68-0 AMBER CORE
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Acute toxicity: oral: LD50> 2000 mg/kg bw (Key study, rel. 1)
Acute toxicity: dermal: LD50> 2000 mg/kg bw (Key study, rel. 1)
Acute inhalation: no data.
Key value for chemical safety assessment
Additional information
Acute toxicity: oral
A key study was identified (Tetsuo Chida, 1992, rel. 1). In this limit acute oral toxicity study performed similarly to the OECD test guideline No. 401 and in compliance with GLP applied to industrial chemicals in Japan (1984), rats were administered a single oral dose of 2000 mg P-#620/kg bw in 0.5% Tween 80 in 0.5% CMC-Na (1.0 mL/100 g) by gavage.No mortality occurred during the study. No abnormal clinical signs were found. No abnormality was revealed at autopsy.
Oral LD50 Combined > 2000 mg/kg bw
Acute toxicity dermal:
A key study was identified (Allan, 1992, rel. 1). In this limit acute dermal toxicity study performed according to the E.U method B.3 and in compliance with GLP, rats were occlusively exposed to undiluted P-#620 at dose of 2000 mg/kg bw. No mortality occurred during the study. There were no signs of systemic reaction to treatment. Sites of application showed no irritation or other dermal changes.No abnormality was revealed at autopsy
Dermal LD50Combined > 2000 mg/kg bw
Justification for classification or non-classification
Harmonized classification:
The test item has no harmonized classification for human health according to the Regulation (EC) No. 1272/2008 including the ATP2 draft.
Self classification:
Oral route:
Based on the available data, the test item is:
- not classified according to the Regulation (EC) No. 1272/2008 as the LD50 is higher than 2000 mg/kg bw
- not classified according to the Directive 67/548/EEC as the LD50 is higher than 2000 mg/kg bw
Dermal route:
Based on the available data, the test item is:
- not classified according to the Regulation (EC) No. 1272/2008 as the LD50 is higher than 2000 mg/kg bw
- not classified according to the Directive 67/548/EEC as the LD50 is higher than 2000 mg/kg bw
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
