Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 412-300-2 | CAS number: 139504-68-0 AMBER CORE
Endpoint summary
Administrative data
Description of key information
Acute toxicity: oral: LD50> 2000 mg/kg bw (Key study, rel. 1)
Acute toxicity: dermal: LD50> 2000 mg/kg bw (Key study, rel. 1)
Acute inhalation: no data.
Key value for chemical safety assessment
Additional information
Acute toxicity: oral
A key study was identified (Tetsuo Chida, 1992, rel. 1). In this limit acute oral toxicity study performed similarly to the OECD test guideline No. 401 and in compliance with GLP applied to industrial chemicals in Japan (1984), rats were administered a single oral dose of 2000 mg P-#620/kg bw in 0.5% Tween 80 in 0.5% CMC-Na (1.0 mL/100 g) by gavage.No mortality occurred during the study. No abnormal clinical signs were found. No abnormality was revealed at autopsy.
Oral LD50 Combined > 2000 mg/kg bw
Acute toxicity dermal:
A key study was identified (Allan, 1992, rel. 1). In this limit acute dermal toxicity study performed according to the E.U method B.3 and in compliance with GLP, rats were occlusively exposed to undiluted P-#620 at dose of 2000 mg/kg bw. No mortality occurred during the study. There were no signs of systemic reaction to treatment. Sites of application showed no irritation or other dermal changes.No abnormality was revealed at autopsy
Dermal LD50Combined > 2000 mg/kg bw
Justification for classification or non-classification
Harmonized classification:
The test item has no harmonized classification for human health according to the Regulation (EC) No. 1272/2008 including the ATP2 draft.
Self classification:
Oral route:
Based on the available data, the test item is:
- not classified according to the Regulation (EC) No. 1272/2008 as the LD50 is higher than 2000 mg/kg bw
- not classified according to the Directive 67/548/EEC as the LD50 is higher than 2000 mg/kg bw
Dermal route:
Based on the available data, the test item is:
- not classified according to the Regulation (EC) No. 1272/2008 as the LD50 is higher than 2000 mg/kg bw
- not classified according to the Directive 67/548/EEC as the LD50 is higher than 2000 mg/kg bw
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
