4-morpholinecarbaldehyde

Acute Toxicity: other routes

Administrative data

Endpoint:

acute toxicity: other routes

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Meets generally accepted scientific standards, irrelevant route of exposure

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1967

Report date:

1967

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

The LD50 after intraperitoneal injection of the test substance into mice was determined.

GLP compliance:

no

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

4-morpholinecarbaldehyde

EC Number:

224-518-3

EC Name:

4-morpholinecarbaldehyde

Cas Number:

4394-85-8

Molecular formula:

C5H9NO2

IUPAC Name:

morpholine-4-carbaldehyde

Details on test material:

- Name of test material (as cited in study report): N-Formylmorpholin
- Physical state: liquid
- Analytical purity: 99.6 %
- pH: neutral
- Storage condition of test material: room temperature

Test animals

Species:

mouse

Strain:

other: Kisslegg

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Weight at study initiation: males: 25-32 g; females: 18-26 g
- no further data

ENVIRONMENTAL CONDITIONS
- no data

Administration / exposure

Route of administration:

intraperitoneal

Vehicle:

water

Remarks:

with Traganth

Details on exposure:

- single i.p. injection
- concentration in vehicle: 20 or 30 % v/v
- Amount of vehicle: 5.0 or 6.25 mL/kg bw of the 30 % test item solution and 8.33, 10.66, 13.33, 16.66 and 21.4 mL/kg bw of the 30 % test item solution

Doses:

1150, 1437.5, 2875, 3680, 4600, 5750, 7360 mg/kg bw (under consideration of absolute density)

No. of animals per sex per dose:

5

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 7 days
- Frequency of observations and weighing: not specified
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs

Statistics:

no data

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

ca. 4 025 mg/kg bw

Based on:

test mat.

Remarks on result:

other: reported as > 3.5 mL/kg bw

Mortality:

- No deaths occurred up to a dose of 2875 mg/kg bw.
- At 3680 mg/kg bw 3/10 animals (2/5 males and 1/5 females) died within 7 days.
- At 4600 mg/kg bw 6/10 animals (2/5 males and 4/5 females) died, 5 of them within 24 hours.
- At 5750 and 7360 mg/kg bw all male and female mice (10/10 each) died within 2-3 hours.

Clinical signs:

Clinical signs observed included: panting and dyspnea, saltatory and rolling convulsions, prone position, apathy, salivation and bristling coat.

Body weight:

no data

Gross pathology:

In some animals adhesions in the abdominal cavity were observed.