Registration Dossier
Registration Dossier
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EC number: 256-289-0 | CAS number: 46948-72-5
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Hazard for air
Hazard for terrestrial organisms
Hazard for predators
Additional information
Conclusion on classification
For the classification of the registration substance one measured value is available for fish. On daphnia and algae only QSAR estimates are available (see table).
6-[Methyl(phenylsulphonyl)amino]hexanoic acid (registration substance), CAS No. 46948 -72 -5
| Species | Guideline | Endpoint | Value | Remark |
| Fish | OECD 203 | LC50 (96h) | 210 mg/L | measured |
| Daphnia | QSAR | EC50 (48h) | 78 mg/L | US EPA EcoSAR 1.0 |
| Algae | QSAR | ErC50 (72h) | 38 mg/L | US EPA EcoSAR 1.0 |
As the registration substance is not readily biodegradable and no chronic data are available. The classification is therefore based on acute data with the lowest ErC50 of 38 mg/L (QSAR US EPA EcoSAR 1.0). This results in the following classification
CLP 1272/2008/EC
Acute (short-term) aquatic hazard: no classification
Chronic (long-term) aquatic hazard: Category Chronic 3, M factor = 1
DSD 67/548/EEC
R52/53
For comparison reasons the data for the metabolite of the registration substance is given as well. The metabolite formed by biodegradation is more polar and less toxic than the registration substance.
6-[Methyl(phenylsulphonyl)amino]hexanoic acid (metabolite), CAS No. 46948 -72 -5
| Species | Guideline | Endpoint | Value | Remark |
| Fish | OECD 203 | LC50 (96h) | >1000 mg/L | measured |
| Daphnia | QSAR | EC50 (48h) | 240 mg/L | measured |
| Algae | QSAR | ErC50 (72h) | 179 mg/L | measured |
Based on these measured data no classification is required for the metabolite neither under CLP nor DSD. Algae is the most sensitive species and the toxicity pattern is in line with the predictions for the registration substance.
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