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Description of key information

Key value for chemical safety assessment

Additional information

There are no studies available for the determination of toxicokinetics or dermal absorption.

Pentaerythritol, oligomeric reaction products with 1-chloro-2,3-epoxypropane, reaction products with acrylic acid is a slightly yellow liquid with a molecular weight of 790-910g/mol, and a low vapour pressurebelow 0.01 hPa. In agreement with its logPow of >3 the water solubility is relatively low (app 700mg/l). The molecular weight below 1000g/mol favours absorption after oral exposure, but might limit dermal or inhalation uptake. But since sensitization was observed and hydrolysis of the substance is expected to occur on the skin dermal absorption cannot be excluded. Water solubility between 100-10,000mg/l and a logPoW just above 4 will also rather favour oral and dermal uptake. Uptake via inhalation is expected to be low due to the low vapour pressure. In an acute dermal and oral toxicity study, no signs of systemic toxicity were observed, either because of limited uptake or the relative non-toxicity of the test substance, as was also observed for the structurally related compound.