Registration Dossier
Registration Dossier
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EC number: 611-591-5 | CAS number: 57903-73-8
Endpoint summary
Administrative data
Description of key information
LD50 p.o. rat: > 2000 mg/kg bw (BASF SE, 2013)
LD50 dermal: > 2000 mg/kg bw (BASF SE, 2013)
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 2 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 2 000 mg/kg bw
Additional information
Acute oral toxicity:
In an acute oral toxicity study performed according to the Acute Toxic Class method, 2000 mg/kg bw (BASF SE, 2013) of the undiluted test item Pentaerythritol, olig. react. prod. with 1- chloro-2,3-epoxypropane, react. prod. with acrylic acid were administered to two test groups of three fasted Wistar rats by gavage. No mortality occured. The LD50 was > 2000 mg/kg bw.
Acute dermal toxicity:
In an acute dermal toxicity study (Limit Test), young adult Wistar rats (5 males and 5 females) were dermally exposed to a single dose of 2000 mg/kg bw (BASF SE, 2013) of the undiluted test item Pentaerythritol, olig. react. prod. with 1-chloro-2,3-epoxypropane, react. prod. with acrylic acid to the clipped skin (dorsal and dorso-lateral parts of the trunk) and covered by semi-occlusive dressing for 24 hours. The application area comprised at least 10% of the total body surface area. The animals were observed for 14 days. No mortality occurred. The LD50 was > 2000 mg/kg bw.
In accordance with column 2 of REACH Annex VIII, no acute inhalation toxicity study was conducted as two other routes are provided.
Justification for classification or non-classification
EU classification according to Annex VI of the Directive 67/548/EEC: no classification required
GHS classification (GHS UN rev.3, 2009): no calssification required
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