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Ecotoxicological information

Short-term toxicity to fish

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Description of key information

The submission item is considered to be acutel y toxic to fish.

Key value for chemical safety assessment

LC50 for freshwater fish:
1.76 mg/L

Additional information

There are conflicitng data available on the acute toxicity to fish of the registration item. A GLP guideline study according to OECD 203 performed with an analogous UVCB revealed a LC50 of 1.76 mg/L. However, a study of the same validity with the submission item resulted in a LC50 of >160 mg/L. In order to add further information, a QSAR estimation using the OECD toolbox was performed. This method predicts a LC50 value of 4.73 mg/L for a representative structure of the registration item. As the reason for the differences in the outcome of the investigations remains unclear, a valid conclusion on the acute fish toxicity of the registration item can´t be drawn. Nevertheless, and applying a worst case approach, a LC50 of 1.76 mg/L is used value for the chemical safety assessment.