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EC number: 282-810-6 | CAS number: 84434-11-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1982
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Acute toxicity upon intraperioneal injection within a 14-observation period.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Ethyl phenyl(2,4,6-trimethylbenzoyl)phosphinate
- EC Number:
- 282-810-6
- EC Name:
- Ethyl phenyl(2,4,6-trimethylbenzoyl)phosphinate
- Cas Number:
- 84434-11-7
- Molecular formula:
- C18H21O3P
- IUPAC Name:
- ethyl phenyl(2,4,6-trimethylbenzoyl)phosphinate
- Details on test material:
- - Name of test material (as cited in study report): Initiator 654
- Physical state: liquid
- Expiration date of the lot/batch: Feb. 1983
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Acclimatization period: Acclimatization in the animal care unit for at least one week.
Age of animals at beginning of study: About 12 weeks
Type of cage: Type DK-III stainless steel wire mesh cages (supplied by Becker & Co., Castrop-Rauxel, FRG)
Number of animals per cage: 5
Animal identification: Identification groups using cage cards
Room temperature: 20 - 26°C
Relative humidity: 45 - 75%
Change of air: 15 - 20 times/hour
Day/night rhythm: 12 h/12 h (6.00 - 18 00 hours/18.00 - 6.00 hours)
Drinking water: Fully demineralized water each workday, ad libitum; tap water on public holidays, ad libitum
Diet: SSNIFF R; Ssniff Versuchstierdiäten, Soest, FRG
Fasting period: 16 hours before administration, water available ad libitum
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- CMC (carboxymethyl cellulose)
- Remarks:
- 0.5% in water
- Details on exposure:
- Preparation with 0.5% aqueous carboxymethyl cellulose
Reason for the vehicle: Aqueous formulation corresponds to the physiological medium
Form of administration: Emulsion
Application volume: 10 ml/kg - Doses:
- 215, 681, 1000, 1470, 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- Observation period: 14 days
Cageside observation: Recording of signs and symptoms < 15', 15', 30', 1 h, 2 h, 4 h, and 5 h after administration of test substance and then once each workday. Check for moribund and dead animals twice each workday and once daily at weekends and on public holidays.
Pathology: Withdrawal of feed 16 hours before sacrifice with CO2, followed by necropsy and gross-pathological examination. All animals that died were necropsied as early as possible.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 470 mg/kg bw
- Mortality:
- 215, 681 and 1000 mg/kg: no deaths after 14 days; 1470 mg/kg: 4/10 died within 2 days; 2000 mg/kg: 10/10 died within 1 day
- Clinical signs:
- Male animals:
All groups showed dyspnea, apathy, staggering, and poor general state.
Animals of the 3 highest doses also showed atonia, paresis, clonic convulsions, fasciculation, and abnormal position (also oberseved in animals treated with 681mg/kg)
Furthermore, high dose animals exhibited stertor, spasmodic respiration, absent pain reflex, narcotic like state, exsiccosis, and salivation (also in the 1470mg/kg group)
Additionally, trembling, twitching, tonus with stretching or bending, straub reaction, piloerection, erythema, and disequilibrium were oberserved in some of the dose groups.
Female animals:
All groups showed dyspnea, apathy, staggering, and poor general state.
All except low dose animals exhibited atonia, paresis, abnormal position.
Fasciculation and salivation were observed in the 3 highest doses.
In high dose females spasmodic respiration, absent pain reflex, narcotic like state, trembling (also animals receiving 1470mg/kg), exsiccosis, disequilibrium, clonic convulsions (also animals receiving 1470mg/kg) were also noted.
Additionally, twitching, tonus with stretching or bending, straub reaction, piloerection, erythema, exopthalamus, and cachexia were oberserved in some of the dose groups.
Clinical signs were observed for a maximum of 2 h in the two lowest dose groups, up to about 1 day in the mid dose animals, and for several days or until death in the two highest dose groups. - Body weight:
- Mean body weight male animals: 194 g at study start, 280 g after 13 days
Mean body weight female animals: 188 g at study start, 230 g after 13 days - Gross pathology:
- Animals that died (male & female): Intraabdominal precipitates of the test substance.
Sacrificed animals (male & female): Liver: Considerably rounded lobes and adhesions of the individual lobes to each other; liver/spleen/kidneys: milky coatings, adhesions of liver, stomach, and spleen occasionally.
Applicant's summary and conclusion
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