Ethyl phenyl(2,4,6-trimethylbenzoyl)phosphinate

Hydrolysis

Link to relevant study record(s)

Reference

Endpoint:

hydrolysis

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2004

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)

Version / remarks:

(Directive 92/69/EEC, C.7)

GLP compliance:

yes (incl. QA statement)

Radiolabelling:

no

Analytical monitoring:

yes

Buffers:

Demineralized water (Milli-Q system)
buffer pH 4.0 (Bemd Kraft GmbH ; citric acid, sodium chloride, sodium hydroxide)
buffer pH 7.0 (Bernd Kraft GmbH ; phosphate mixture)
buffer pH 9.0 (Riedel de Haën; sodium borate, hydrochloric acid)
acetonitrile (Riedel-de Haën)
buffer pH = 4 (GKA reference material A 21491041LC_824)
buffer pH = 10 (GKA reference material A 22571031LC_824) for testing of pH meter.

Transformation products:

not measured

pH:

4

Temp.:

70 °C

DT50:

158 h

Type:

(pseudo-)first order (= half-life)

pH:

7

Temp.:

30 °C

DT50:

114 h

Type:

(pseudo-)first order (= half-life)

pH:

9

Temp.:

50 °C

DT50:

< 2.4 h

Type:

(pseudo-)first order (= half-life)

Validity criteria fulfilled:

not specified

Conclusions:

The substance was found to be stable at pH 4 and 7, respectively, but hydrolyses at pH 9 with a half-life below 2.4 hours at 50°C.

Description of key information

The study was conducted to recognised testing guidelines, and with GLP certification.

Key value for chemical safety assessment

Half-life for hydrolysis:

158 h

at the temperature of:

70 °C