Registration Dossier
Registration Dossier
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EC number: 209-943-4 | CAS number: 598-63-0
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 9 weeks
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented publication which meets basic scientific principles
Data source
Reference
- Reference Type:
- publication
- Title:
- Effets de l'intoxication par le plomb sur les propriétés des mitochondries de cerveau de jeune rat
- Author:
- Paul Dumas, Daniel Gueldry, Annie Loireau, Philoppe Chomard, Anne-Marie Buthieau and Nicole Autissier
- Year:
- 1 985
- Bibliographic source:
- C. R. Biol. 179, 175-183
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Young Wistar rats of 14d were fed with powdered chow containing lead carbonate during some weeks.
- GLP compliance:
- not specified
- Test type:
- fixed dose procedure
- Limit test:
- no
Test material
- Reference substance name:
- Lead carbonate
- EC Number:
- 209-943-4
- EC Name:
- Lead carbonate
- Cas Number:
- 598-63-0
- Molecular formula:
- CH2O3.Pb
- IUPAC Name:
- λ²-lead(2+) carbonate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 1,2 and 4%
- No. of animals per sex per dose:
- 1% : 10mice + 7 controls
2%
4% - Control animals:
- yes
Results and discussion
Any other information on results incl. tables
Growth is clearly slowed at 1% of lead carbonate in food.
During 9 weeks, weight of test mice were lower than controls as the concentration of lead carbonate increased. Moreover, cerebral mitochondrial cells accumulated lead consecutively to the lead carbonate concentration in food.
In vitro trials showed that lead accumulated in mitochondrial cells induced alteration, whereas in vivo results were ambiguous : lead is accumulated as an insoluble less toxic form thanks to a complexation with inorganic phosphate.
Applicant's summary and conclusion
- Interpretation of results:
- sligthly toxic
- Remarks:
- Migrated information Criteria used for interpretation of results: not specified
- Conclusions:
- In the conditions of the study, lead carbonate was found to be slightly toxic.
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