Registration Dossier
Registration Dossier
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EC number: 209-943-4 | CAS number: 598-63-0
Neurotoxicity
Administrative data
- Endpoint:
- neurotoxicity: acute oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented publication which meets basic scientific principles
Data source
Reference
- Reference Type:
- publication
- Title:
- The pathogenesis of lead encephalopathy. Effects of lead carbonate feedings on morphology, lead content, and mitochondrial respiration in brains of immature and adult rats.
- Author:
- Hsu JS, Herman MM, Hsu HJ, Mortell P
- Year:
- 1 980
- Bibliographic source:
- VIRCHOWS ARCH A PATHOL ANAT HISTOL; 387 (2).
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The toxic effects of inorganic lead feedings on the immature brain were studied in the rat pup.
PbCO3 was fed to nursing mothers and then to pups directly after weaning. Results in lead-fed pups were compared to age-matched controls and to lead-fed young adult males (60 days old). - GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Lead carbonate
- EC Number:
- 209-943-4
- EC Name:
- Lead carbonate
- Cas Number:
- 598-63-0
- Molecular formula:
- CH2O3.Pb
- IUPAC Name:
- λ²-lead(2+) carbonate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- unchanged (no vehicle)
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 2 d: 7 animals
1 wk: 3 animals
2 wk: 3 animals - Frequency of treatment:
- ad libitum
Doses / concentrations
- Remarks:
- Doses / Concentrations:
4 %
Basis:
nominal in diet
- Control animals:
- yes, plain diet
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- Altered mitochondrial respiration occurs early in regional and age-dependent association with lead encephalopathy in the rat pup.
The development of lead encephalopathy also is associated with increased mitochondrial lead concentrations.
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