Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

biotransformation and kinetics
Type of information:
experimental study
Adequacy of study:
other information
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable, well-documented publication which meets basic scientific principles

Data source

Reference Type:
study report

Materials and methods

Test guideline
no guideline followed
Principles of method if other than guideline:
Bioaccessibility measurement of soil samples from 4 locations at a site contaminated with mining waste and located in a high carbonate soil in the south of France. The test consists a 3-step extraction procedure and simulates the chemical processes occuring in the mouth, stomach and intestine compartments using synthetic digestive solutions.
GLP compliance:
not specified
Type of medium:

Test material

Constituent 1
Reference substance name:

Results and discussion

Transformation products:
not specified

Any other information on results incl. tables

For all soil samples Pb bioavailability was significantly higher in the saliva-gastric phase compared to the intestinal phase. Higher bioavailability in gastric phase is due to the lower pH which facilitated lead dissolution.

Sequential extraction was used and allowed to detect that PbCO3 was not occuring anymore in the residual fractions.

Applicant's summary and conclusion

This study confirms that Pb carbonate forms and particularly Cerussite are highly bioaccessible.