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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
developmental toxicity
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable, well-documented publication which meets basic scientific principles

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1980

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Rat pups were chronically exposed from birth to 40 ppm of Pb and tested behaviorally and biochemically at 25 to 35 days of age.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Lead carbonate
EC Number:
209-943-4
EC Name:
Lead carbonate
Cas Number:
598-63-0
Molecular formula:
CH2O3.Pb
IUPAC Name:
λ²-lead(2+) carbonate

Test animals

Species:
rat
Strain:
Sprague-Dawley

Administration / exposure

Route of administration:
oral: feed
Vehicle:
not specified
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
25 to 35 days
Frequency of treatment:
Rats were given food ad libitum.
Doses / concentrations
Remarks:
Doses / Concentrations:
4% (31.016 ppm)
Basis:
nominal in diet
No. of animals per sex per dose:
8
Control animals:
yes

Results and discussion

Results: maternal animals

Effect levels (maternal animals)

Dose descriptor:
NOAEL
Effect level:
31.016 ppm
Basis for effect level:
other: developmental toxicity
Remarks on result:
not determinable
Remarks:
no NOAEL identified

Results (fetuses)

Details on embryotoxic / teratogenic effects:
Embryotoxic / teratogenic effects:not examined

Fetal abnormalities

Abnormalities:
not specified

Overall developmental toxicity

Developmental effects observed:
not specified

Any other information on results incl. tables

Locomotor activity after chronic postnatal PbCO3 exposure: Pb-exposed rat pups demonstrated locomotor hyperactivity, but the locomotor response to d-amphetamine SO4 (0.5-2.0mg/kg) or apomorphine HCI (0.5-5.0 mg/k) was attenuated.

Prejunctional alterations at DA synapses after chronic postnatal PbCO3 exposure: Synaptosomes from 25-, 30- and 35-day old Pb-exposed rat pups showed the same capacity to synthesize DA as did those obtained from pair-fed control animals.

Accumulation of [3H]DA by rat forebrain slices: No change in the Tissue/Medium ratio for [3H]DA was noted in slices from PbCO3- exposed rat pups.

Postjunctional alterations at DA synapses after chronic postnatal PbCO3 exposure: The activity of adenylate cyclase in the absence of DA or apomorphine (basal activity) was unchanged by chronic PbCO3- exposure.

Applicant's summary and conclusion

Conclusions:
n the conditions of the study, lead carbonate was found toxic to development of rat by causing locomotor activity alterations at chronic doses.