Registration Dossier
Registration Dossier
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EC number: 263-974-8 | CAS number: 63157-72-2
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
- Principles of method if other than guideline:
- Based on H.F. Smyth et al. (1962), Am. lnd. Hyg. Ass. J. 23, 95-107.
The test was performed in principle as described in OECD test guideline 403. It demonstrates the toxicity of an atmosphere saturated with vapors of the volatile components of a test substance at 20 °C. Young adult laboratory rats, 3 per sex, were exposed sequentially to the vapors generated by bubbling 200 L/h air through a substance column of about 5 cm above a fritted glass disc in a glass cylinder for 8 h. - GLP compliance:
- no
- Test type:
- other: Inhalation hazard test
- Limit test:
- no
Test material
- Reference substance name:
- Tris[4-(diethylamino)phenyl]methylium acetate
- EC Number:
- 263-974-8
- EC Name:
- Tris[4-(diethylamino)phenyl]methylium acetate
- Cas Number:
- 63157-72-2
- Molecular formula:
- C31H42N3.C2H3O2
- IUPAC Name:
- tris[4-(diethylamino)phenyl]methylium acetate
- Details on test material:
- - Name of test material (as cited in study report): Ethylviolett fluessig
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: male: 227 g (mean)/ female: 180 g (mean)
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Temperature in air chamber: 20 °C
- Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 8 h
- Concentrations:
- 7.56 mg/l, corresponding to ca. 3.02 mg/l EVA
- No. of animals per sex per dose:
- 6
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 7.56 mg/L air
- Based on:
- other: preparation containing ca. 40% ethylviolet acetate, ca. 17% acetic acid, ca. 17% confidential component and ca. 26% water
- Exp. duration:
- 8 h
- Remarks on result:
- other: no mortality
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 4.32 mg/L air
- Based on:
- other: registered substance
- Exp. duration:
- 8 h
- Remarks on result:
- other: no mortality
- Mortality:
- No mortality was observed.
- Clinical signs:
- other: No symptoms were observed.
- Body weight:
- male: 227 g / female: 180 g
- Gross pathology:
- During necropsy nothing abnormal was detected.
Applicant's summary and conclusion
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