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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1978
Report date:
1978

Materials and methods

Principles of method if other than guideline:
Based on H.F. Smyth et al. (1962), Am. lnd. Hyg. Ass. J. 23, 95-107.
The test was performed in principle as described in OECD test guideline 403. It demonstrates the toxicity of an atmosphere saturated with vapors of the volatile components of a test substance at 20 °C. Young adult laboratory rats, 3 per sex, were exposed sequentially to the vapors generated by bubbling 200 L/h air through a substance column of about 5 cm above a fritted glass disc in a glass cylinder for 8 h.
GLP compliance:
no
Test type:
other: Inhalation hazard test
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Tris[4-(diethylamino)phenyl]methylium acetate
EC Number:
263-974-8
EC Name:
Tris[4-(diethylamino)phenyl]methylium acetate
Cas Number:
63157-72-2
Molecular formula:
C31H42N3.C2H3O2
IUPAC Name:
tris[4-(diethylamino)phenyl]methylium acetate
Details on test material:
- Name of test material (as cited in study report): Ethylviolett fluessig

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Weight at study initiation: male: 227 g (mean)/ female: 180 g (mean)



Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
not specified
Vehicle:
other: unchanged (no vehicle)
Details on inhalation exposure:
GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Temperature in air chamber: 20 °C


Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
8 h
Concentrations:
7.56 mg/l, corresponding to ca. 3.02 mg/l EVA
No. of animals per sex per dose:
6
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes

Results and discussion

Effect levelsopen allclose all
Sex:
male/female
Dose descriptor:
LC50
Effect level:
> 7.56 mg/L air
Based on:
other: preparation containing ca. 40% ethylviolet acetate, ca. 17% acetic acid, ca. 17% confidential component and ca. 26% water
Exp. duration:
8 h
Remarks on result:
other: no mortality
Sex:
male/female
Dose descriptor:
LC50
Effect level:
> 4.32 mg/L air
Based on:
other: registered substance
Exp. duration:
8 h
Remarks on result:
other: no mortality
Mortality:
No mortality was observed.
Clinical signs:
other: No symptoms were observed.
Body weight:
male: 227 g / female: 180 g
Gross pathology:
During necropsy nothing abnormal was detected.

Applicant's summary and conclusion