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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1978
Report Date:
1978

Materials and methods

Principles of method if other than guideline:
Based on H.F. Smyth et al. (1962), Am. lnd. Hyg. Ass. J. 23, 95-107.
The test was performed in principle as described in OECD test guideline 403. It demonstrates the toxicity of an atmosphere saturated with vapors of the volatile components of a test substance at 20 °C. Young adult laboratory rats, 3 per sex, were exposed sequentially to the vapors generated by bubbling 200 L/h air through a substance column of about 5 cm above a fritted glass disc in a glass cylinder for 8 h.
GLP compliance:
no
Test type:
other: Inhalation hazard test
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Ethylviolett fluessig

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female
Details on test animals and environmental conditions:
TEST ANIMALS
- Weight at study initiation: male: 227 g (mean)/ female: 180 g (mean)



Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
not specified
Vehicle:
other: unchanged (no vehicle)
Details on inhalation exposure:
GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Temperature in air chamber: 20 °C


Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
8 h
Concentrations:
7.56 mg/l, corresponding to ca. 3.02 mg/l EVA
No. of animals per sex per dose:
6
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes

Results and discussion

Effect levelsopen allclose all
Sex:
male/female
Dose descriptor:
LC50
Effect level:
> 7.56 mg/L air
Based on:
other: preparation containing ca. 40% ethylviolet acetate, ca. 17% acetic acid, ca. 17% confidential component and ca. 26% water
Exp. duration:
8 h
Remarks on result:
other: no mortality
Sex:
male/female
Dose descriptor:
LC50
Effect level:
> 4.32 mg/L air
Based on:
other: registered substance
Exp. duration:
8 h
Remarks on result:
other: no mortality
Mortality:
No mortality was observed.
Clinical signs:
No symptoms were observed.
Body weight:
male: 227 g / female: 180 g
Gross pathology:
During necropsy nothing abnormal was detected.

Applicant's summary and conclusion