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EC number: 700-003-3 | CAS number: 56519-71-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

PBT assessment
Administrative data
PBT assessment: overall result
- PBT status:
- the substance is not PBT / vPvB
- Justification:
The PBT Assessment for Propanediol dicaprylate (CAS 56519-71-2) is based on the criteria set out in the “Guidance on information requirements and chemical safety assessment, Chapter R.11: PBT Assessment” (ECHA, 2012).
Persistence
Propanediol dicaprylate is considered to be readily biodegradable.
According to the Guidance on information requirements and chemical safety assessment Chapter R.11 (PBT assessment, 2012), a substance does not fulfill the criterion “persistent (P)” and very persistent (vP)” if it is readily biodegradable: “If the substance is readily biodegradable, or if the criteria for ready biodegradability are fulfilled with exception of the 10-day window, there is no reason to perform further biodegradation tests for PBT/vPvB assessment. The conclusion is that the substance is not fulfilling the criteria for Persistence (P)”.
The substance is shown to be readily biodegradable in a Manometric Respirometry Test according to OECD guideline 301F with a biodegradation of 75% after 28 days fulfilling the 10-day window criterion. Therefore, the half-life data in the different environmental compartments are expected to be below the cut-off values for persistency given in Annex XIII of Regulation (EC) 1907/2006.
It can be concluded that the substance is not regarded as persistent (P) or very persistent (vP).
Bioaccumulation
The bioaccumulation of propanediol dicaprylate is considered to be low.
According to Annex XIII of Regulation (EC) 1907/2006 and according to the Guidance on information requirements and chemical safety assessment Chapter R.11 (PBT assessment, 2012) a substance does not fulfill the criterion “bioaccumulative (B)” or “very bioaccumulative (vB)” if the BCF is below 2000 or the log Kow is below 4.5.
There are no experimental data on BCF available. The experimentally determined log Kow according to OECD 117 is 7.6 and above the screening criterion for the bioaccumulation criterion (log Kow =4.5). However, at very high log Kow (>6), the relationship between log Kow and bioconcentration potential is decreasing. The substance is rapidly metabolised and excreted by organisms and thus an accumulation is not expected. This is supported by calculated low BCF/BAF values (BCF/BAF: 11-11.6 L/kg; Arnot-Gobas estimate, upper trophic). According to Guidance on information requirements and chemical safety assessment (2012) Chapter R.11, Figure R.11-2, no further testing is required to conclude on the Bioaccumulation criterion as “not P” is already confirmed. The substance is not considered to be B or vB.
Toxicity
Propanediol dicaprylate is considered to be not toxic.
According to Annex XIII of Regulation (EC) 1907/2006 and according to the Guidance on information requirements and chemical safety assessment (2012) Chapter R.11 PBT assessment a substance does not fulfill the criterion if the long-term NOEC for marine or freshwater organisms is less than 0.01 mg/l and if there is no evidence of chronic toxicity and no classification as carcinogenic (Cat. 1, 2), mutagenic (Cat. 1, 2) or toxic for reproduction (Cat 1, 2, 3) considering human health.
As the substance is not toxic and not classified for human health these criteria are not fulfilled. Furthermore, experimental studies on acute aquatic toxicity on Daphnia and Lemna showed no toxicity up to the limit of water solubility (EC50 > 100mg/l for Lemna based on yield and growth, and the EC50 > 100 mg/l for Daphnia immobilization). Additionally, in a weight of evidence approach on short term toxicity to fish the predicted toxicity was determined to be above water solubility.A long term toxicity to fish was experimentally assessed and no toxicity was highlighted with a NOEC ≥ 10 mg test item/L.
Finally,a long term aquatic toxicity on daphnia magna was experimentally assessed and no toxicity was highlighted with a NOEC ≥ 10 mg test item/L .
Therefore, according to Guidance R.11 (2012), table R.11-3, it can be concluded that the substance presumably not fulfills the Toxicity criteria of the PBT criteria.Conclusion
In conclusion the substance is not considered to meet the criteria to be classified as PBT or vPvB based on the available data.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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