Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

LD50 = 128.0 mg/kg-oral male rat
LD50 = 148.3 mg/kg-oral female rat
4h-LC50 = 0.034 mg/L-inhalation rat
Acute dermal data of this substance is scientifically waived due to low potential based on irritative but not corrosive property to skin, and low Kow (1.09) is not supposed to be absorbed through the skin.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
128 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Dose descriptor:
34 mg/m³ air

Additional information

In relation to the dermal route of exposure, this substance is a skin irritant and there was an absence of systemic toxicity from oral studies by rat. so that acute toxicity study by dermal can be waived due to the strictly controlled conditions used by polymer manufacturers. So, this product is not classified by acute dermal toxicity on GHS.

In relation to the inhalation route of exposure, intristic hazadous properties determined from the experimental data (GHS Category 1) are significantly mitigated from a risk perspective as commercial product (substance) has practically no respirable fraction (all componens with a particle size of >355 um). So, this product (>355um) is not classified by acute inhalation toxicity on GHS .

Justification for classification or non-classification

Category 3 (oral) as LD50 is between 50 and 300 mg/kg bw (128 mg/kg bw)

Category 1 (inhalation) as LD50 is less than 0.05 mg/l (0.034 mg/l). This however is limited to micronized particle <10 um.

Acute toxicity-irreversible damage after single exposure: non-classification due to the irritative property and absence of systemic toxicity.