3-acetamido-5-amino-4-hydroxybenzenesulphonic acid

Endpoint summary

Additional information

Aquatic Toxicity :

Short-term toxicity to Fish :

The lethal concentration (LC50) value of phthalylsulfathiazole in fish (Pimephales promelas) in a 96 hr study on mortality effect was estimated to be 245.685mg/L. The supporting studies also predicted an LC50 value above 100 mg/L

Sr. No	Endpoint name	Value	Units	Species
1	LC50	245.685	mg/l	Pimephales promelas
2	LC50	152.0679	mg/l	Oncorhynchus mykiss
3	LC50	147.8293	mg/l	Lepomis macrochirus

Therefore it can be concluded that the substance is not classified as per CLP criteria.

Short -term toxicity to Aquatic invertebrate :

The LC50 value of 3-acetamido-5-amino-4-hydroxybenzenesulphonic acid in aquatic invertebrate (Daphnia Magna) in a 48 hr study on mortality was estimated to be 718.3787 mg/L. No of studies reviewed for Short term toxicity to aquatic invertebrate and the results have been summarised below:

Sr. No	Endpoint name	Value	Units	Species
1	LC50	718.3787	mg/l	Daphnia Magna
2	EC50	120.2614	mg/l	Daphnia Magna
3	LC50	107.762	mg/l	Daphnia Magna
4	LC 50	284.638	mg/l	Daphnia Magna

 

Based on the above endpoint values of QSAR and supporting studies(ECOSAR) and considering the CLP Criteria for aquatic classification it can be concluded that the substance3-acetamido-5-amino-4-hydroxybenzene sulphonic acid does not exhibit short term toxicity to aquatic invertebrate (Daphnia Magna).Therefore it can be concluded that the substance is not classified.

Toxicity to aquatic algae and cynobacteria :

The effective concentration (EC50) value of 3-acetamido-5-amino-4-hydroxybenzenesulphonic acid in aquatic algae (Pseudokirchneriella subcapitata) in a 72 hr study based upon effect on growth was estimated to be 199.5558 mg/L. The summary of the results are presented below

 

Sr. No	Endpoint name	Value	Units	Species
1	EC 50	199.5558	mg/l	Pseudokirchneriella subcapitata
2	EC 50	179.126	mg/l	Green algae
3	EC 50	380.534	mg/l	Green algae

 

Based on the above endpoint value of QSAR and supporting studies(ECOSAR) and considering the CLP Criteria for aquatic classification it can be concluded that the substance3-acetamido-5-amino-4-hydroxybenzene sulphonic acid do not exhibit short term toxicity to aquatic algae (Pseudokirchneriella subcapitata) .Therefore it can be concluded that the substance is not classified as per the CLP criteria.

Toxicity to microorganism :

Toxicity value(IG50 -46 h) of 3-acetamido-5-amino-4-hydroxybenzenesulphonic acid to Tetrahymena pyriformis on the basis of growth inhibition is estimated as 309.9978 mg/L indicating that the substance do not have toxic effect on micro-organism.