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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Genetic toxicity: in vitro

Currently viewing:

Administrative data

Endpoint:
in vitro DNA damage and/or repair study
Remarks:
Type of genotoxicity: DNA damage and/or repair
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
other: Authoritative data base
Title:
Danish QSAR study for CAS No.: 98-42-0
Author:
Danish EPA Model
Year:
2012
Bibliographic source:
QSAR predictions by Danish Environmental Protection Agency (EPA)model powered by OASIS database:-DK-EPA

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Modelling Database
Principles of method if other than guideline:
Multicase model.
GLP compliance:
no
Type of assay:
DNA damage and repair assay, unscheduled DNA synthesis in mammalian cells in vitro

Test material

Constituent 1
Chemical structure
Reference substance name:
3-amino-4-methoxybenzenesulphonic acid
EC Number:
202-667-5
EC Name:
3-amino-4-methoxybenzenesulphonic acid
Cas Number:
98-42-0
Molecular formula:
C7H9NO4S
IUPAC Name:
3-amino-4-methoxybenzenesulfonic acid

Method

Species / strain
Species / strain / cell type:
hepatocytes: Rat hepatocytes
Additional strain / cell type characteristics:
not specified
Metabolic activation:
not specified
Test concentrations with justification for top dose:
no data

Results and discussion

Test results
Species / strain:
hepatocytes: Rat hepatocytes
Metabolic activation:
not specified
Genotoxicity:
negative
Cytotoxicity / choice of top concentrations:
not specified
Vehicle controls validity:
not specified
Untreated negative controls validity:
not specified
Positive controls validity:
not specified
Remarks on result:
other: all strains/cell types tested
Remarks:
Migrated from field 'Test system'.

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information):
negative

Unscheduled DNA synthesis in Rat hepatocyte is negative for 3-amino-4-methoxybenzenesulphonic acid
Executive summary:

Unscheduled DNA synthesis in Rat hepatocyte is negative for 3-amino-4-methoxybenzenesulphonic acid