Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 258-476-2 | CAS number: 53320-86-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 09-25 February 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study carried out in a GLP facility by trained personnel using recommended OECD test methods
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 420 (Acute Oral Toxicity - Fixed Dose Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- Silicic acid, lithium magnesium sodium salt
- EC Number:
- 258-476-2
- EC Name:
- Silicic acid, lithium magnesium sodium salt
- Cas Number:
- 53320-86-8
- Molecular formula:
- Na0.7[Li0.3Mg5.5Si8O20(OH)4]
- IUPAC Name:
- magnesium(2+) lithium(1+) sodium bis(oxosilanebis(olate))
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- arachis oil
- Doses:
- 2000mg/kg body weight dosed once only
- No. of animals per sex per dose:
- Five female rats in total
- Control animals:
- no
Results and discussion
- Preliminary study:
- One female rat was dosed with 10 ml/kg oral gavage with the 200mg/ml of the test material in arachis oil giving a total initial dose of 2000mg/kg body weight. No mortality was observed so a further 4 female rats were treated to the same dose.
Effect levels
- Sex:
- female
- Dose descriptor:
- LD0
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- None
- Clinical signs:
- other: Hunched posture on day of dosing in three rats. Nothing after that.
- Gross pathology:
- No abnormalities were noted at necropsy
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information no deaths nor abnormalities Criteria used for interpretation of results: EU
- Conclusions:
- This test material showed no signs of being acutely toxic by oral exposure to rats
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
