Silicic acid, lithium magnesium sodium salt

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1988

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Test carried out by GLP compliant laboratory to recognised validated methods by trained personnel

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1988

Report date:

1988

Materials and methods

Test guideline

Qualifier:

no guideline available

Principles of method if other than guideline:

Wistar albino rats were checked for health issues and acclimatised for at least 7 days prior to test initiation. They were housed in controlled humidity and temperature conditions in a day/night cycle. Equal numbers of males / females were used and weighed prior to the test. Ten rats were used. They were placed in a 95litre plexglass chamber. Air flow was 5l/min and the test material was introduced via this air stream at a static concentration of 200mg/litre for a period of 1 hour. After exposure the rats were returned to their cage and observed for signs of pharmacotoxic effects and mortality 1,3,6 and 24 hours after exposure and then daily for 14 days. After this time the rats were euthenased and subjected to gross necropsy.

GLP compliance:

yes

Test type:

fixed concentration procedure

Test material

Test material information

Constituent 1

Reference substance name:

Silicic acid, lithium magnesium sodium salt

EC Number:

258-476-2

EC Name:

Silicic acid, lithium magnesium sodium salt

Cas Number:

53320-86-8

Molecular formula:

Na0.7[Li0.3Mg5.5Si8O20(OH)4]

IUPAC Name:

magnesium(2+) lithium(1+) sodium bis(oxosilanebis(olate))

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Administration / exposure

Route of administration:

inhalation: dust

Type of inhalation exposure:

whole body

Vehicle:

air

Analytical verification of test atmosphere concentrations:

not specified

Duration of exposure:

60 min

Concentrations:

200 mg/litre

No. of animals per sex per dose:

5 males, 5 females

Control animals:

no

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LC50

Effect level:

> 200 mg/L air

Based on:

test mat.

Exp. duration:

60 min

Mortality:

None

Clinical signs:

other: Slight redenning of nasal discharge in 7 out of 10 rats 1 hour after exposure but then normal for the remainder of the observation period for all ten animals.

Applicant's summary and conclusion

Interpretation of results:

practically nontoxic

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

This test substance is not toxic to rats by inhalation under conditions of this test