Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

The test substance 1,1,2-trichloro-1,2,2-trifluoroethane (source chemical of read-across) demonstrated negative results in several in vivo Guinea Pig Maximisation Tests.

The skin sensitisation potential of the target chemical 1,1,1-trichloro-2,2,2-trifluoroethane is determined by read-across from in vivo Guinea Pig Maximisation Tests with the source chemical 1,1,2-trichloro-1,2,2-trifluoroethane. The analogue approach is justified in Section 13 (Assessment Reports_Read-Across, in attachment CAS_354-58-5_Read-Across.pdf). As a consequence 1,1,1-trichloro-2,2,2-trifluoroethane is not considered as a skin sensitiser.

In accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.2, the available data for skin sensitisation potential is considered to be adequate for the purposes of risk assessment, and classification and labelling, based on the weight-of-evidence.


Migrated from Short description of key information:
negative results in in vivo Guinea Pig Maximisation Tests on the test substance 1,1,2-trichloro-1,2,2-trifluoroethane

Justification for classification or non-classification

The substance demonstrated negative results in several in several in vivo Guinea Pig Maximisation Tests. As a result the substance does not meet the criteria for classification (sensitisation by skin contact) under Directive 67/548/EEC, as amended for the 28th time in Directive 2001/59/EC, Annex VI, 3.2.7.2.

The substance demonstrated negative results in several in several in vivo Guinea Pig Maximisation Tests. As a result the substance does not meet the criteria for classification (skin sensitisers) under Regulation (EC) 1272/2008, Annex I, Part 3, 3.4.2.2.