Registration Dossier
Registration Dossier
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EC number: 471-920-1 | CAS number: -
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
In a key study performed in accordance with the State Environmental Protection Administration of China. The Guidelines for testing of chemicals, 204 Fish Prolonged Toxicity Test: 14-day study, 2004 and China National Technical Committee for Standardisation of Dangerous Chemicals Management. GB/T 21808 - 2008 Testing of chemicals - Fish prolonged toxicity: 14-day test. Beijing 2008 Zebra fish (10 per test group) were exposed to nominal test concentrations of 54 or 108 mg/L Loading Rate WAF for 14 days in a semi-static prolonged toxicity test. Observations on mortality abnormalities, body weight and body length were made throughout the 14 -day test period. A blank control without test substance was run in parallel with the test concentrations. A positive reference control (potassium dichromate) was used to verify the test conditions.
There were no mortalities in either the test groups or the blank control. No abnormalities in behaviour or morphology were observed in any group. The results of a positive control and a blank control confirm the validity of the test system.
The LC50 (14 d) in Zebra fish is > 108 mg/L Loading Rate WAF
The substance is not classified for acute toxicity and is readily biodegradable. It is not classified as PBT or vPvB. Furthermore chronic NOEC values are available for Daphnia and algae which are the more sensitive species in acute studies. The CSR did not trigger any concern for long-term exposure therefore in the absence of toxicity in the prolonged toxicity studies further chronic toxicity studies in fish are scientifically unjustified.
Key value for chemical safety assessment
Additional information
In a key study performed in accordance with the State Environmental Protection Administration of China. The Guidelines for testing of chemicals, 204 Fish Prolonged Toxicity Test: 14-day study, 2004 and China National Technical Committee for Standardisation of Dangerous Chemicals Management. GB/T 21808 - 2008 Testing of chemicals - Fish prolonged toxicity: 14-day test. Beijing 2008 Zebra fish (10 per test group) were exposed to nominal test concentrations of 54 or 108 mg/L Loading Rate WAF for 14 days in a semi-static prolonged toxicity test. Observations on mortality abnormalities, body weight and body length were made throughout the 14 -day test period. A blank control without test substance was run in parallel with the test concentrations. A positive reference control (potassium dichromate) was used to verify the test conditions.
There were no mortalities in either the test groups or the blank control. No abnormalities in behaviour or morphology were observed in any group. The results of a positive control and a blank control confirm the validity of the test system.
The LC50 (14 d) in Zebra fish is > 108 mg/L Loading Rate WAF
The substance is not classified for acute toxicity and is readily biodegradable. It is not classified as PBT or vPvB. Furthermore chronic NOEC values are available for Daphnia and algae which are the more sensitive species in acute studies. The CSR did not trigger any concern for long-term exposure therefore in the absence of toxicity in the prolonged toxicity studies further chronic toxicity studies in fish are scientifically unjustified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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