Registration Dossier
Registration Dossier
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EC number: 471-920-1 | CAS number: -
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The 48–hr-acute toxicity of test substance to Daphnia magna was studied under static conditions. Daphnids were exposed to control, and test chemical at the 13, 22, 36, 60, 100 mg/L loading rates (mean measured concentrations: 0.019, 0.064, 0.17, 1.1, 2.9 mg/L) for 48 hr. Immobilization effects were observed daily. The 48– hour EC50was 77 mg/L (1.3 mg/L as mean measured). The 48– hr NOEC based on immobilization was 13 mg/L (0.17 mg/L as mean measured).
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 77 mg/L
Additional information
Two studies, one key and one supporting are available:
The 48–hr-acute toxicity of test substance to Daphnia magna was studied under static conditions. Daphnids were exposed to control, and test chemical at the 13, 22, 36, 60, 100 mg/L loading rates (mean measured concentrations: 0.019, 0.064, 0.17, 1.1, 2.9 mg/L) for 48 hr. Immobilization effects were observed daily. The 48– hour EC50was 77 mg/L (1.3 mg/L as mean measured). The 48– hr NOEC based on immobilization was 13 mg/L (0.17 mg/L as mean measured).
The 48–hr-acute toxicity of test substance toDaphnia magnawas studied under static conditions. Daphnids were exposed to control, and test chemical at the nominal 100, 180, 320, 560, and 1000 mg/L loading rates for 48 hr. Immobilization effects were observed daily.
Due to the complex nature of WAFs and the observed changes in peak profile between the WAFs and the analytical standards, the results calculated from the GC and the TOC analyses should be viewed with caution as these may not be reliable indicators of the concentration of the test material present in the WAFs. The use of nominal loading rates is therefore considered a more appropriate indicator for the expression of the results of this study.
Nominal Loading rates: The 48– hour EC50 was 180mg/L. loading rate WAF. The 48– hr NOEC based on immobilization was 100 mg/L loading rate WAF.
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