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Toxicological information

Additional toxicological data

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Administrative data

Endpoint:
additional toxicological information
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Publication peer reviewed.

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1993

Materials and methods

Type of study / information:
In vitro hepatotoxicity (cytotoxicity)
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): trichloroacetic acid (TCA)
- Analytical purity: 99%

Results and discussion

Any other information on results incl. tables

Trichloroacetic acid produced no evidence of cytotoxicity in hepatocytes from naive or clofibric acid-pretreated animals of either species at concentrations up to 5.0 mM. Trichloroacetic acid did not alter cellular glutathione (GSH) status in hepatocytes isolated from either Sprague-Dawley rats or B6C3F1 mice. It was concluded from these in vitro observations that trichloroacetic acid is not highly cytotoxic to hepatocytes.

Applicant's summary and conclusion

Conclusions:
It was concluded from these in vitro observations that trichloroacetic acid is not highly cytotoxic to hepatocytes.
Executive summary:

In the present study the in vitro cytotoxicity of trichloroacetic acid was determined in hepatocyte suspensions prepared from naive and clofibric acid-pretreated male Sprague-Dawley rats and B6C3F1 mice. Trichloroacetic acid produced no evidence of cytotoxicity in hepatocytes from naive or clofibric acid-pretreated animals of either species at concentrations up to 5.0 mM. Trichloroacetic acid did not alter cellular GSH status in hepatocytes isolated from either Sprague-Dawley rats or B6C3F1 mice. It was concluded from these in vitro observations that trichloroacetic acid is not highly cytotoxic to hepatocytes.