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Toxicological information

Exposure related observations in humans: other data

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Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Results on treatment of photodamaged skin with trichloroacetic acid.

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1996

Materials and methods

Type of study / information:
The use of trichloroacetic acid as a chemical peel.
Principles of method if other than guideline:
Sixteen men with actinic damage including actinic keratoses were treated with a 40% trichloroacetic acid (TCA) chemical peel. Half were pretreated for 6 weeks with topical tretinoin; they also used tretinoin after the peel. Photographs were obtained at baseline and at 6 weeks and 6 months after treatment. Changes in specific features were rated by a panel of three examiners.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): trichloroacetic acid (TCA)

Results and discussion

Results:
Some improvement was noted in all patients. More rapid and even frosting was observed in the patients pretreated with tretinoin. Solar lentigines, actinic keratoses, and skin texture were the features of photoaging most affected; wrinkles were least affected. No statistically significant difference was found between patients treated with trichloroacetic acid and tretinoin (before and after peel) and those with trichloroacetic acid alone.

Applicant's summary and conclusion

Conclusions:
A medium-depth chemical peel with 40% trichloroacetic acid alone produced moderate improvement in some manifestations of actinic damage but had little effect on wrinkles. Treatment with tretinoin before and after trichloroacetic acid did not significantly enhance the efficacy of the peel.
Executive summary:

Sixteen men with actinic damage including actinic keratoses were treated with a 40% trichloroacetic acid chemical peel. Half were pretreated for 6 weeks with topical tretinoin; they also used tretinoin after the peel. Photographs were obtained at baseline and at 6 weeks and 6 months after treatment. Changes in specific features were rated by a panel of three examiners. Some improvement was noted in all patients. More rapid and even frosting was observed in the patients pretreated with tretinoin. Solar lentigines, actinic keratoses, and skin texture were the features of photoaging most affected; wrinkles were least affected. No statistically significant difference was found between patients treated with trichloroacetic acid and tretinoin (before and after peel) and those with trichloroacetic acid alone. A medium-depth chemical peel with 40% trichloroacetic acid alone produced moderate improvement in some manifestations of actinic damage but had little effect on wrinkles. Treatment with tretinoin before and after trichloroacetic acid did not significantly enhance the efficacy of the peel.