Registration Dossier

Administrative data

Workers - Hazard via inhalation route

Systemic effects

Long term exposure
Hazard assessment conclusion:
low hazard (no threshold derived)
Acute/short term exposure
Hazard assessment conclusion:
low hazard (no threshold derived)
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
low hazard (no threshold derived)
Acute/short term exposure
Hazard assessment conclusion:
low hazard (no threshold derived)
DNEL related information

Workers - Hazard via dermal route

Systemic effects

Long term exposure
Hazard assessment conclusion:
low hazard (no threshold derived)
Acute/short term exposure
Hazard assessment conclusion:
low hazard (no threshold derived)
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
low hazard (no threshold derived)
Acute/short term exposure
Hazard assessment conclusion:
low hazard (no threshold derived)

Workers - Hazard for the eyes

Local effects

Hazard assessment conclusion:
low hazard (no threshold derived)

Additional information - workers

It has not been possible to determine reliable no-effect levels as no adverse effects have been noted from testing performed on similar substances or from data available on the degradation products. 

 

If swallowed, the substance will quickly hydrolyse to titanium dioxide, triethanolamine, propan-2-ol and propylene glycol. None of these substances are classified as hazardous and although some pH effects from contact with the amine may result in local irritation, this has not been reported from testing. 

 

The substance is a viscous liquid with minimal risk of inhalation. If on contact with skin, it is likely that there will be exposure to the degradation products; none of these are considered harmful to the skin.

 

From public documents, the organic degradation products will themselves be readily metabolised if ingested and there is little evidence that the titanium dioxide will be absorbed. 

 

For the IUCLD endpoints, a read-across titanate has been cited for some of the endpoints, but other references have also been added. 

General Population - Hazard via inhalation route

Systemic effects

Long term exposure
Hazard assessment conclusion:
low hazard (no threshold derived)
Acute/short term exposure
Hazard assessment conclusion:
low hazard (no threshold derived)
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
low hazard (no threshold derived)
Acute/short term exposure
Hazard assessment conclusion:
low hazard (no threshold derived)
DNEL related information

General Population - Hazard via dermal route

Systemic effects

Long term exposure
Hazard assessment conclusion:
low hazard (no threshold derived)
Acute/short term exposure
Hazard assessment conclusion:
low hazard (no threshold derived)
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
low hazard (no threshold derived)
Acute/short term exposure
Hazard assessment conclusion:
low hazard (no threshold derived)

General Population - Hazard via oral route

Systemic effects

Long term exposure
Hazard assessment conclusion:
low hazard (no threshold derived)
Acute/short term exposure
Hazard assessment conclusion:
low hazard (no threshold derived)
DNEL related information

General Population - Hazard for the eyes

Local effects

Hazard assessment conclusion:
low hazard (no threshold derived)

Additional information - General Population

It has not been possible to determine reliable no-effect levels as no adverse effects have been noted from testing performed on similar substances or from data available on the degradation products. 

 

If swallowed, the substance will quickly hydrolyse to titanium dioxide, triethanolamine, propan-2-ol and propylene glycol. None of these substances are classified as hazardous and although some pH effects from contact with the amine may result in local irritation, this has not been reported from testing. 

 

The substance is a viscous liquid with minimal risk of inhalation. If on contact with skin, it is likely that there will be exposure to the degradation products; none of these are considered harmful to the skin.

 

From public documents, the organic degradation products will themselves be readily metabolised if ingested and there is little evidence that the titanium dioxide will be absorbed. 

 

For the IUCLD endpoints, a read-across titanate has been cited for some of the endpoints, but other references have also been added.