Registration Dossier

Administrative data

Key value for chemical safety assessment

Effects on fertility

Effect on fertility: via oral route
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
NOAEL
1 000 mg/kg bw/day
Quality of whole database:
Extensive data has been determined for the key degradation products showing an absence of systemic toxic effects, rapid metabolism of organic components and lack of accumulation of titanium salts. Performing further animal studies is not justified on the basis of the existing toxicity review.
Effect on fertility: via inhalation route
Endpoint conclusion:
no study available
Effect on fertility: via dermal route
Endpoint conclusion:
no study available
Additional information
Short description of key information:
Extensive data has been determined for the key degradation products showing an absence of systemic toxic effects, rapid metabolism of organic components and lack of accumulation of titanium salts. Performing further animal studies is not justified on the basis of the existing toxicity review.

Effects on developmental toxicity

Effect on developmental toxicity: via oral route
Endpoint conclusion:
no study available
Additional information
Justification for selection of Effect on developmental toxicity: via oral route:
Extensive data has been determined for the key degradation products showing an absence of systemic toxic effects, rapid metabolism of organic components and lack of accumulation of titanium salts. Performing further animal studies is not justified on the basis of the existing toxicity review.

Justification for classification or non-classification