Registration Dossier
Registration Dossier
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EC number: 202-605-7 | CAS number: 97-74-5
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- GLP compliance:
- not specified
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- 1.17
- Temp.:
- 20 °C
- Remarks on result:
- other: No pH reported
- Details on results:
- No data
- Conclusions:
- Log P was determined equal to 1.17
- Executive summary:
The determination of the partition coefficient (n-octanol/water; Poct) of TMTM was conducted in triplicate in accordance with OECD guideline 107. Log P was determined equal to 1.17
Reference
No data
Description of key information
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 1.17
- at the temperature of:
- 20 °C
Additional information
The determination of the partition coefficient (n-octanol/water) of TMTM was conducted in triplicate in accordance with OECD guideline 107. Log P was determined equal to 1.17.
As the substance falls within the applicability domain of the model, the use of QSAR to predict the Log Kow is an appropriate method and is suitable as a supporting study: the Log Kow for tetramethylthiuram monosulphide is calculated to be 0.75, which confirms the low value obtained with experimentation.
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