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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
test procedure in accordance with national standard methods with acceptable restrictions

Data source

Reference
Reference Type:
publication
Title:
Effet sur le systeme nerveux central du monosulfure de tetramethylthiurame comparaison avec le disulfirame.
Author:
Poitou, P. Marignac, B. et Gradiski, D.
Year:
1978
Bibliographic source:
J.Pharmacol., 9/1, 35-44.

Materials and methods

Principles of method if other than guideline:
Rats were treated with TMTM by ip.
GLP compliance:
no
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Tetramethylthiuram monosulphide
EC Number:
202-605-7
EC Name:
Tetramethylthiuram monosulphide
Cas Number:
97-74-5
Molecular formula:
C6H12N2S3
IUPAC Name:
N,N-dimethyl[(dimethylcarbamothioyl)sulfanyl]carbothioamide
Details on test material:
no data

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: EVIC CEBA
- Age at study initiation:
- Weight at study initiation: 200g
- Fasting period before study:
- Housing:
- Diet (e.g. ad libitum):
- Water (e.g. ad libitum):
- Acclimation period:

ENVIRONMENTAL CONDITIONS
- Temperature (°C):
- Humidity (%):
- Air changes (per hr):
- Photoperiod (hrs dark / hrs light):

IN-LIFE DATES: From: To:

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
olive oil
Details on exposure:
Administration volume = 5 ml/kg
Doses:
no data
No. of animals per sex per dose:
10 animals /dose/sex
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
Statistics:
ANOVA method

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC50
Effect level:
383 mg/kg bw
Based on:
test mat.
95% CL:
361 - 403
Mortality:
no data
Clinical signs:
hypothermia, hypoactivity
Body weight:
no data
Gross pathology:
no data

Applicant's summary and conclusion

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