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EC number: 202-605-7 | CAS number: 97-74-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- April-September 1987
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 81-3 (Acute inhalation toxicity)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Thiram
- EC Number:
- 205-286-2
- EC Name:
- Thiram
- Cas Number:
- 137-26-8
- Molecular formula:
- C6H12N2S4
- IUPAC Name:
- [disulfanediylbis(carbonothioylnitrilo)]tetramethane
- Reference substance name:
- tetramethylthiuram disulfide
- IUPAC Name:
- tetramethylthiuram disulfide
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): thiram technical
- Physical state: fine white powder
- Analytical purity: 99.5%
- Lot/batch No.: M.5.1841; G3380
- Storage condition of test material: room temperature
- Median particle size: 5.61 µm
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source:Harlan Sprague-Dawley, Inc. Hoston, Texas, USA
- Age at study initiation: yound adult
- Weight at study initiation: 242-350g (male), 178-219g (female)
- Fasting period before study:no data
- Housing: 1-3 per cage, males separate from females
- Diet (e.g. ad libitum): Purina Formulab Chow #5008 ad libitum
- Water (e.g. ad libitum):tap water ad libitum
- Acclimation period: at least one week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): no data
- Humidity (%): no data
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): no data
Temperature and humidity were recorded at 30 minutes intervals during the exposure period from a Taylor wet hygrometer located in the exposure room.
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: dried filtered air
- Details on inhalation exposure:
- The arerosol was generated by passing a stream of dry, filtered air though either two (for the lower exposure concentration) or four (for the higher exposure concentration) glass flasks containing the test material.The concentrated aerosol was then diluted with dried and filtered air and drawn into the exposure cahmber. Air flow into the chamber was maintained through the use of a calibrated critical orifice. Air flow was recorded at 30 minute intervals during the exposure period. The air flow was sufficient to ensure adequate oxygen content of the exposure atmosphere. Temperature and humidity were recorded at 30 minutes intervals during the exposure period from a Taylor wet hygrometer located in the exposure room.
- Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- determined gravimetrically twice per hour (Anderson cascade impactor)
- Duration of exposure:
- 4 h
- Concentrations:
- Nominal concentrations: 6.9, 14.1, 32.03 mg/L
Analytical concentrations: 2.06, 3.36, 5.04 mg/L (gravimetric) - No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- Observations for mortality and pharmacologic and/or toxicologica effects were made frenquently on the day of exposure and at least one daily thereafter for 14 days (day of exposure considered Day 0). Individual body weights were recorded just prior to the inhalation exposure and on Days 7 and 14 or a time of discovery after death. A gross necropsy examination was conducted on each animal at termination of the study or at the time of discovery after death.
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 4.42 mg/L air (analytical)
- Based on:
- test mat.
- 95% CL:
- 3.09 - 6.32
- Exp. duration:
- 4 h
- Remarks on result:
- other: LC50 calculated
- Key result
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- > 5.04 mg/L air (analytical)
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: One male died at each dose
- Key result
- Sex:
- female
- Dose descriptor:
- LC50
- Effect level:
- 3.464 mg/L air (analytical)
- Based on:
- test mat.
- 95% CL:
- 2.98 - 4.03
- Exp. duration:
- 4 h
- Remarks on result:
- other: LC50 calculated
- Mortality:
- 2.06 mg/L: one male died, no female died (10%)
3.36 mg/L: one male and two females died (30%)
5.04 mg/L: one male and five females died (60%) - Clinical signs:
- other: Clinical signs were observed at all doses. Prominent in-life observations included activity decrease, constricted pupils, gasping, nasal discharge, piloerection, polyurea, ptosis and salivation.
- Body weight:
- A decrease of body weight was observed.
- Gross pathology:
- Treatment related gross necropsy findings: lacrimation, nasal discharge, polyuria, salivation, discoloration of the contents of the stomach, stomach distended with gaz, discoloration of lungs and variations thereof.
- Other findings:
- no
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute inhalation LC-50 with 95% confidence limits afor actual thiram technical when administered undiluted as an aerosol to abino rats were calculated: the males LC50 was higher than 5.04 mg/L, the female LC50 was equal to 3.46 [2.96 -4.03] mg/L , and the combined LC50 was equal to 4.42 [3.09 -6.32] mg/L.
- Executive summary:
An acute inhalation toxicity study was conducted on male and female albino rats using test material thiram technical.
The animals were exposed for 4 hours to an aerosol generated from the undiluted test material (fine powder). Five males and five females were exposed to the following levels: 2.06, 3.36 and 5.04 mg/L. One male exposed to 2.06 mg/L died during the study. One male and two females exposed to 3.36 mg/L doed during the study. One male and five females exposed to 5.04 mg/L died during the study. The acute inhalation LC-50 with 95% confidence limits afor actual thiram technical when administered undiluted as an aerosol to abino rats were calculated: the males LC50 was higher than 5.04 mg/L, the female LC50 was equal to 3.46 [2.96 -4.03] mg/L , and the combined LC50 was equal to 4.42 [3.09 -6.32] mg/L. Prominent in-life observations included activity decrease, constricted pupils, gasping, nasal discharge, piloerection, polyurea, ptosis and salivation. Moreover a decrease of body weight was observed in treated animals. Treatment related gross necropsy findings: lacrimation, nasal discharge, polyuria, salivation, discoloration of the contents of the stomach, stomach distended with gaz, discoloration of lungs and variations thereof.
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