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Toxicity to microorganisms

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Description of key information

3-hydroxy-2-(3-hydroxy-2-quinolyl)-1H-inden-1-one showed 5.087 % respiration inhibition of activated sludge at the highest test item concentration of 1000 mg/L. An EC10 and an EC50 of >1000 mg/L were obtained in this test. The effect value relates to nominal concentration, since no analytical monitoring was performed. A NOEC of > 1000 mg/L was calculated.

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Additional information

In order to test the toxicity to mircoorganism of 3-hydroxy-2-(3-hydroxy-2-quinolyl)-1H-inden-1-one, activated sludge from predominantly domestic sewage plant was exposed to the test solution of a nominal concentration of 3-hydroxy-2-(3-hydroxy-2 -quinolyl)-1H-inden-1-one (1000 mg/L), blank control solution and solution with positive reference substance for a period of 3 hours.

Dissolved oxygen was recorded and respiration rates were calculated. No physico-chemical oxygen consumption was observed at the concentration of 3-hydroxy-2-(3-hydroxy-2-quinolyl)-1H-inden-1-one. Only a respiration inhibition was observed at 5.087 %.A NOEC of > 1000 mg/L was calculated.This toxicity study is classified as acceptable and satisfies the guideline requirement for the toxicity study to microorganisms.