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Administrative data

Description of key information

3-hydroxy-2-(3-hydroxy-2-quinolyl)-1H-inden-1-one is regarded as non-toxic after oral and dermal applications.

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: the study is performed in 1980 similar to the guideline of nowadays, GLP not menioned
Qualifier:
no guideline followed
Principles of method if other than guideline:
Single dose administered; observation period 14 days; 5 male and 5 female rats tested.
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes
Species:
rat
Strain:
Wistar
Sex:
male/female
Route of administration:
oral: gavage
Vehicle:
water
Doses:
5000 mg/kg
No. of animals per sex per dose:
5 males and 5 females
Control animals:
no
Sex:
male/female
Dose descriptor:
discriminating dose
Effect level:
5 000 mg/kg bw
Based on:
test mat.

No deaths, no clinical signs, no gross pathological findings at the end of the 14 days observation period.

Executive summary:

After single dosing of 5 male and 5 female rats with 5000 mg/kg no deaths, no clinical signs and no gross pathological findings were reported.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available
Quality of whole database:
An acute Inhalation Toxicity study was initiated. The study was aborded before any animal was exposed to the compound based on the low maximal technical producible concentration that could be achieved.

Acute toxicity: via dermal route

Link to relevant study records
Reference
Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2015
Reliability:
1 (reliable without restriction)
Qualifier:
according to
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
GLP compliance:
yes (incl. certificate)
Test type:
standard acute method
Limit test:
yes
Species:
rat
Strain:
Wistar
Sex:
male/female
Type of coverage:
semiocclusive
Vehicle:
unchanged (no vehicle)
Duration of exposure:
24 h
Doses:
2000 mg/kg
No. of animals per sex per dose:
5 males and 5 females
Control animals:
not required
Sex:
male/female
Dose descriptor:
discriminating dose
Effect level:
2 000 mg/kg bw
Based on:
test mat.

Groups of 5 male and 5 female Wistar rats received a single dermal dose of 2000 mg/kg body weight of the test item applied semiocclusively for 24 hours.

A dose of 2000 mg/kg body weight was tolerated by male and female rats without toxicologically relevant clinical signs, mortalities, toxicological effects on body weight development and gross pathological findings.

Executive summary:

Groups of 5 male and 5 female Wistar rats received a single dermal dose of 2000 mg/kg body weight of the test item applied semiocclusively for 24 hours.

A dose of 2000 mg/kg body weight was tolerated by male and female rats without toxicologically relevant clinical signs, mortalities, toxicological effects on body weight development and gross pathological findings.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed

Additional information

In an acute oral toxicity study conducted in 1990 no deaths, no clinical signs and no gross pathological findings were reported after dosing of 5 male and 5 female rats with 5000 mg/kg.

In an acute dermal study 5 male and 5 female rats received a single dose of 2000 mg/kg of the test item applied semiocclusively for 24 hours. Rats tolerated the dose without toxicologically relevant clinical signs, mortalities, toxicological effects on body weight development and gross pathological findings.

An acute inhalation toxicity study was initiated in 2014. The study was aborded before any animal was exposed to the compound based on the low maximal technical producible concentration that could be achieved.

Justification for classification or non-classification

3-hydroxy-2-(3-hydroxy-2-quinolyl)-1H-inden-1-one is regarded as non-toxic after oral and dermal applications