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Toxicological information

Genetic toxicity: in vitro

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Administrative data

Endpoint:
in vitro DNA damage and/or repair study
Remarks:
Type of genotoxicity: DNA damage and/or repair
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study meets generally accepted scientific participles, acceptable for assessment

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Methylglyoxal-induced DNA-protein cross-links and cytotoxicity in Chinese hamster ovary cells
Author:
Brambilla G, Sciaba L, Faggin P et al.
Year:
1985
Bibliographic source:
Carcinogenesis 6: 683-686
Reference Type:
publication
Title:
DNA-damaging activity of biotic and xenobiotic aldehydes in Chinese hamster ovary cells
Author:
Marinari, U.M. et al.
Year:
1984
Bibliographic source:
Cell Biochem. Funct. 2 (4), 243-248

Materials and methods

Principles of method if other than guideline:
Alkaline Elution: Kohn, K.W.: Methods Cancer Res. 16, 291-345 (1979)
GLP compliance:
not specified
Type of assay:
other: Alkaline Elution

Test material

Reference
Name:
Unnamed
Type:
Constituent

Method

Species / strain
Species / strain:
other: CHO-cells
Metabolic activation:
with and without
Test concentrations with justification for top dose:
0.5, 1.5, 4.5 mM
Details on test system and conditions:
Alkaline Elution Assay: DNA damage and repair assay

Results and discussion

Test results
Species / strain:
Chinese hamster Ovary (CHO)
Metabolic activation:
with and without
Genotoxicity:
positive
Cytotoxicity:
not specified

Applicant's summary and conclusion