Registration Dossier
Registration Dossier
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EC number: 202-770-5 | CAS number: 99-59-2
Endpoint summary
Administrative data
Description of key information
Additional information
Aquatic Toxicity :
Short-term toxicity to Fish :
The lethal concentration (LC50) value of 5-nitro-o-anisidine in fish (Pimephales promelas) in a 96 h study on mortality effect was estimated to be 207.4058mg/L. The supporting studies also predicted an LC50 value above 207.4 mg/L
The various weight of evidence studies can be summarised as follows :
Sr. No |
Endpoint name |
Value |
Unit | Species | Basis of effect |
| 1 | LC50 | 207.4058 | mg/L | Pimephales promelas | mortality |
| 2 | EC50 | 139.0646 | mg/L | Lepomis macrochirus | mortality |
| 3 | LC50 | 119.1158 | mg/L | Oncorhynchus mykiss | mortality |
But the BCF value of 5-nitro-o-anisidine reported was not >= 500 as well as the substance was found to be rapidly degradable.Thus considering only the value from CLP Criteria for aquatic classification of the substance , it is concluded that 5-nitro-o-anisidine could not exhibit short term toxicity to fish (Pimephales promelas).
Short -term toxicity to Aquatic invertebrate :
The no observed effect concentration (NOEC) value of 5-nitro-o-anisidine in aquatic invertebrate (Daphnia magna) in a 48 hr study based on intoxicaton effect was estimated to be 133.3612 mg/L. Thus considering the value from CLP Criteria for aquatic classification of the substance , it is concluded that 5 -nitro-o-anisidine could not exhibit short term toxicity to aquatic invertebrate (Daphnia Magna).
Toxicity to aquatic algae and cynobacteria :
The No observed effect concentration (NOEC) value of 5-nitro-o-anisidine in green algae (Pseudokirchnerella subcapitata) in a 72 hr study was estimated to be 6.645622mg/L (growth effect). But the BCF value of 5-nitro-o-anisidine reported was not >= 500 as well as the substance was found to be rapidly degradable.Thus considering the CLP Criteria for aquatic classification of the substance , it is concluded that 5-nitro-o-anisidine could not exhibit short term toxicity to green algae (Pseudokirchnerella subcapitata)
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