Registration Dossier

Ecotoxicological information

Endpoint summary

Administrative data

Description of key information

Additional information

Aquatic Toxicity :

Short-term toxicity to Fish :

The lethal concentration (LC50) value of 5-nitro-o-anisidine in fish (Pimephales promelas) in a 96 h study on mortality effect was estimated to be 207.4058mg/L. The supporting studies also predicted an LC50 value above 207.4 mg/L

The various weight of evidence studies can be summarised as follows :

Sr. No

Endpoint name

Value

 Unit  Species  Basis of effect
 1  LC50  207.4058  mg/L  Pimephales promelas  mortality
 2  EC50  139.0646  mg/L  Lepomis macrochirus  mortality
 3  LC50  119.1158  mg/L  Oncorhynchus mykiss  mortality

But the BCF value of 5-nitro-o-anisidine reported was not >= 500 as well as the substance was found to be rapidly degradable.Thus considering only the value from CLP Criteria for aquatic classification of the substance , it is concluded that 5-nitro-o-anisidine could not exhibit short term toxicity to fish (Pimephales promelas).

Short -term toxicity to Aquatic invertebrate :

The no observed effect concentration (NOEC) value of 5-nitro-o-anisidine in aquatic invertebrate (Daphnia magna) in a 48 hr study based on intoxicaton effect was estimated to be 133.3612 mg/L. Thus considering the value from CLP Criteria for aquatic classification of the substance , it is concluded that 5 -nitro-o-anisidine could not exhibit short term toxicity to aquatic invertebrate (Daphnia Magna).

Toxicity to aquatic algae and cynobacteria :

The No observed effect concentration (NOEC) value of 5-nitro-o-anisidine in green algae (Pseudokirchnerella subcapitata) in a 72 hr study was estimated to be 6.645622mg/L (growth effect). But the BCF value of 5-nitro-o-anisidine reported was not >= 500 as well as the substance was found to be rapidly degradable.Thus considering the CLP Criteria for aquatic classification of the substance , it is concluded that 5-nitro-o-anisidine could not exhibit short term toxicity to green algae (Pseudokirchnerella subcapitata)