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Description of key information

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6
Qualifier:
according to
Guideline:
other: estimated data
Principles of method if other than guideline:
Prediction is done using QSAR Toolbox version 2.3.
GLP compliance:
no
Test type:
standard acute method
Species:
rat
Strain:
Brown Norway
Sex:
male/female
Route of administration:
oral: unspecified
Vehicle:
not specified
Control animals:
not specified
Sex:
male/female
Dose descriptor:
LD50
Effect level:
2 315.143 mg/kg bw
Based on:
test mat.





The prediction was based on dataset comprised from the following descriptors: LD50
Estimation method: Taking average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain

("a" and ("b" and "c" ) )

Domain logical expression index: "a"

Similarity boundary:Target: c1(OC)c(N)cc(N(=O)=O)cc1
Threshold=50%,
Dice(Atom pairs)

Domain logical expression index: "b"

Parametric boundary:The target chemical should have a value of log Kow which is >= 0.971

Domain logical expression index: "c"

Parametric boundary:The target chemical should have a value of log Kow which is <= 2.06

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The acute oral median lethal dose (LD50) of 5-nitro-o-anisisdine in rat was found to be 2315.143 mg/kg of body weight.
Executive summary:

The acute oral median lethal dose (LD50) of 5-nitro-o-anisisdine in rat was found to be 2315.143 mg/kg of body weight. This value indicates that 5 -nitro-o-anisidine does not exhibit acute toxicity by the oral route.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
2 315.143 mg/kg bw
Quality of whole database:
The data is K2 level as the data has been obtained from QSAR model considered reliable by OECD.

Acute toxicity: via inhalation route

Link to relevant study records
Reference
Endpoint:
acute toxicity: inhalation
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6
Qualifier:
according to
Guideline:
other: estimated data
Principles of method if other than guideline:
Prediction is done using QSAR Toolbox version 2.3.
GLP compliance:
no
Test type:
other: Acute Rodent Inhalation Toxicity Test
Species:
rat
Strain:
other: Wistar;Sprague-Dawley;CnR-CD;Long-Evans
Sex:
not specified
Route of administration:
inhalation
Type of inhalation exposure:
other: Inhalation: Vapor
Vehicle:
not specified
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
4 h
Control animals:
not specified
Sex:
not specified
Dose descriptor:
LC50
Effect level:
218.23
Based on:
test mat.
Exp. duration:
4 h





The prediction was based on dataset comprised from the following descriptors: LC50
Estimation method: Taking average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain

("a" and ("b" and "c" ) )

Domain logical expression index: "a"

Similarity boundary:Target: c1(OC)c(N)cc(N(=O)=O)cc1
Threshold=50%,
Dice(Atom pairs)

Domain logical expression index: "b"

Parametric boundary:The target chemical should have a value of log Kow which is >= 0.347

Domain logical expression index: "c"

Parametric boundary:The target chemical should have a value of log Kow which is <= 3.45

Interpretation of results:
not classified
Remarks:
Migrated information
Conclusions:
The 4h acute inhalation median lethal concentration (LC50) of 5-nitro-o-anisidine in rat was estimated to be 218.23 mg/L. Acute inhalation toxicity of 5-nitro-o-anisidine to rat by inhalative route indicates that the substance does not exhibits acute toxicity by the inhalative route.
Executive summary:

The 4h acute inhalation median lethal concentration (LC50) of 5-nitro-o-anisidine in rat was estimated to be 218.23 mg/L. Acute inhalation toxicity of 5-nitro-o-anisidine to rat by inhalative route indicates that the substance does not exhibits acute toxicity by the inhalative route.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LC50
Value:
218.23 mg/m³
Quality of whole database:
The data is K2 level as the data has been obtained from QSAR model considered reliable by OECD.

Additional information

Acute toxicity oral

The acute oral median lethal dose (LD50) of 5-nitro-o-anisisdine in rat was found to be 2315.143 mg/kg of body weight. This value indicates that 5 -nitro-o-anisidine does not exhibit acute toxicity by the oral route.

The various weight of evidence studies can be summarised as follows :

Acute toxicity :

oral

Sr. No

End point

Species

Effect level

1

LD50

Rattus norvegicus

2315.143 mg/kg of body weight

 

2

LD50

Peromyscus maniculatus

2028.969 mg/kg of body weight

3

LD50

Rat

2250 mg/kg

4

LD50

Mouse

1060 mg/kg

5

LD50

Rabbit

1000 mg/kg

6

LD50

Rat

704 mg/kg

Acute toxicity inhalation

The 4h acute inhalation median lethal concentration (LC50) of 5-nitro-o-anisidine in rat was estimated to be 218.23 mg/L. Acute inhalation toxicity of 5-nitro-o-anisidine to rat by inhalative route indicates that the substance does not exhibits acute toxicity by the inhalative route.


Justification for selection of acute toxicity – oral endpoint
The acute oral median lethal dose (LD50) of 5-nitro-o-anisisdine in rat was found to be 2315.143 mg/kg of body weight. This value indicates that 5 -nitro-o-anisidine does not exhibit acute toxicity by the oral route.

Justification for selection of acute toxicity – inhalation endpoint
The 4h acute inhalation median lethal concentration (LC50) of 5-nitro-o-anisidine in rat was estimated to be 218.23 mg/L. Acute inhalation toxicity of 5-nitro-o-anisidine to rat by inhalative route indicates that the substance does not exhibits acute toxicity by the inhalative route.

Justification for classification or non-classification