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EC number: 202-770-5 | CAS number: 99-59-2
Endpoint summary
Administrative data
Description of key information
The substance 5-nitro-o-anisidine was found to be moderatelly irritating to the human skin and irritating to the human eye.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Qualifier:
- according to guideline
- Guideline:
- other: other guideline:;OECD Guideline 404 (Acute dermal irritation / corrosion)
- Principles of method if other than guideline:
- Prediction is done using QSAR Toolbox version 2.3.
- GLP compliance:
- no
- Species:
- other: rabbit;human
- Type of coverage:
- other: semiocclusive;occlusive
- Preparation of test site:
- not specified
- Vehicle:
- not specified
- Controls:
- not specified
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Score:
- 3.2
- Reversibility:
- no data
- Remarks on result:
- other: moderately irritating
- Interpretation of results:
- moderately irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- By primary dermal irritation index (PDII) from QSAR, skin irritation score of 5-nitro-o-anisidine was estimated as 3.2. Based on this score 5-nitro-o-anisidine was found to be moderately irritating to the human skin.
- Executive summary:
By primary dermal irritation index (PDII) from QSAR, skin irritation score of 5-nitro-o-anisidine was estimated as 3.2. Based on this score 5-nitro-o-anisidine was found to be moderately irritating to the human skin.
Reference
The prediction was based on dataset comprised from the following descriptors: "Primary Irritation Index"
Estimation method: Taking average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
(("a" and "b" ) and ("c" and "d" ) )
Domain logical expression index: "a"
Similarity boundary:Target: c1(OC)c(N)cc(N(=O)=O)cc1
Threshold=50%,
Dice(Atom pairs)
Domain logical expression index: "b"
Similarity boundary:Target: c1(OC)c(N)cc(N(=O)=O)cc1
Threshold=60%,
Dice(Atom pairs)
Domain logical expression index: "c"
Parametric boundary:The target chemical should have a value of log Kow which is >= 0.684
Domain logical expression index: "d"
Parametric boundary:The target chemical should have a value of log Kow which is <= 2.46
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Data is from dose.
- GLP compliance:
- not specified
- Species:
- other: unspecified
- Strain:
- not specified
- Vehicle:
- not specified
- Controls:
- not specified
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Reversibility:
- not specified
- Remarks on result:
- other: irritating
- Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- According to the DOSE, the substance 2-nitro-p-anisidine exhibit irritating effect.
- Executive summary:
According to the DOSE, the substance 2 -nitro-p-anisidine exhibit irritating effect.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Skin irritation:-
By primary dermal irritation index (PDII) from QSAR, skin irritation score of 5-nitro-o-anisidine was estimated as 3.2. Based on this score 5-nitro-o-anisidine was found to be moderately irritating to the human skin.
Eye irritation:-
According to the DOSE, the substance 5-nitro-o-anisidine exhibit irritating effect.
Justification for selection of skin irritation / corrosion endpoint:
By primary dermal irritation index (PDII) from QSAR, skin irritation score of 5-nitro-o-anisidine was estimated as 3.2. Based on this score 5-nitro-o-anisidine was found to be moderately irritating to the human skin.
Justification for selection of eye irritation endpoint:
According to the DOSE, the substance 5-nitro-o-anisidine exhibit irritating effect.
Effects on skin irritation/corrosion: moderately irritating
Effects on eye irritation: irritating
Justification for classification or non-classification
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