Registration Dossier
Registration Dossier
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EC number: 204-515-3 | CAS number: 122-01-0
Toxicity to reproduction
Administrative data
- Endpoint:
- screening for reproductive / developmental toxicity
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- publication
- Title:
- 4-chlorobenzoyl chloride / 122-01-0
- Author:
- National Institute of Health Sciences / Kawasaki / Japan
- Year:
- 2 019
- Bibliographic source:
- https://dra4.nihs.go.jp/
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 422 (Combined Repeated Dose Toxicity Study with the Reproduction / Developmental Toxicity Screening Test)
- Deviations:
- no
- GLP compliance:
- yes
- Limit test:
- no
Test material
- Reference substance name:
- 4-chlorobenzoyl chloride
- EC Number:
- 204-515-3
- EC Name:
- 4-chlorobenzoyl chloride
- Cas Number:
- 122-01-0
- Molecular formula:
- C7H4Cl2O
- IUPAC Name:
- 4-chlorobenzoyl chloride
- Reference substance name:
- p-Chlorbenzoylchlorid
- IUPAC Name:
- p-Chlorbenzoylchlorid
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Crj: CD(SD)
Administration / exposure
- Route of administration:
- oral: gavage
Results and discussion
Results: P0 (first parental generation)
Effect levels (P0)
- Dose descriptor:
- NOAEL
- Effect level:
- 500 mg/kg bw/day (actual dose received)
- Remarks on result:
- other: no effects on reproduction
Results: P1 (second parental generation)
Effect levels (P1)
- Dose descriptor:
- NOAEL
- Effect level:
- 100 mg/kg bw/day (actual dose received)
- Basis for effect level:
- other: decreades body weight on day 0 an 4 post natal
Applicant's summary and conclusion
- Conclusions:
- NOAEL in F1 is 100 mg / kg bw / day and results from decreades body weight of pups on day 0 and 4 post natal. This does not result in classification as toxic to reproduction.
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