Registration Dossier
Registration Dossier
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EC number: 204-515-3 | CAS number: 122-01-0
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- short-term repeated dose toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- publication
- Title:
- 4-chlorobenzoyl chloride / 122-01-0
- Author:
- National Institute of Health Sciences / Kawasaki / Japan
- Year:
- 2 019
- Bibliographic source:
- https://dra4.nihs.go.jp/
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 422 (Combined Repeated Dose Toxicity Study with the Reproduction / Developmental Toxicity Screening Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Limit test:
- no
Test material
- Reference substance name:
- 4-chlorobenzoyl chloride
- EC Number:
- 204-515-3
- EC Name:
- 4-chlorobenzoyl chloride
- Cas Number:
- 122-01-0
- Molecular formula:
- C7H4Cl2O
- IUPAC Name:
- 4-chlorobenzoyl chloride
- Reference substance name:
- p-Chlorbenzoylchlorid
- IUPAC Name:
- p-Chlorbenzoylchlorid
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Crj: CD(SD)
Administration / exposure
- Route of administration:
- oral: gavage
- Duration of treatment / exposure:
- Males: 42 days including 14 days pre-mating, mating, and thereafter 14 days (P)Females: 42–48
days including 14 days pre-mating, mating and gestation periods and the days until day 4 of lactation
- No. of animals per sex per dose:
- 12
Results and discussion
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- 100 mg/kg bw/day (actual dose received)
- Sex:
- male/female
Applicant's summary and conclusion
- Conclusions:
- No observed adverse effect level (NOAEL) for repeated oral dosing was determined to be 100 mg/kg bw/
day in male and female rats. The available data do not support a classification as repeated dose organ toxic.
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