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EC number: 203-781-8 | CAS number: 110-59-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1983
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: the study was performed according to OECD-/EU-testing guidelines, but not under GLP; therefore the study was considered to have Klimisch 2
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- Version / remarks:
- Dir. 79/831/EEC, Annex V
- Deviations:
- no
- Principles of method if other than guideline:
- not applicable
- GLP compliance:
- no
Test material
- Reference substance name:
- Valeroniitrile
- IUPAC Name:
- Valeroniitrile
- Details on test material:
- - Physical state: Colourless liquid
- Density: 0.804
- Quantity of test sample: ca. 200 g
- Date of receipt: 7 February 1983
- pH-value: 9.6 (measured during test)
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: several accredited breeders
- Weight at study initiation: ca. 2.5 kg (+/- 200 g)
- Housing: individual housing on polystyrene cages with perforated polystyrene floor
- Diet (e.g. ad libitum): 150 g per rabbit & day of complete maintenance food (granulés Lapin Entretien "112" UAR, 91360 Villemoisson, Orge)
- Water (e.g. ad libitum): softened and filtered tap water
- Acclimation period: 8 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20°C (+/- 3°C)
- Humidity (%): 30-70%
- Air changes (per hr): 12 times per hour (pre-filtered air 15 µm)
- Photoperiod (hrs dark / hrs light): artificial light for 12 hours
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 0.1 ml of test item as such was instilled in the eye conjunctival sac. Eyes were not rinsed at the end of treatment.
- Duration of treatment / exposure:
- 24 hours
- Observation period (in vivo):
- Observation 1 hour, 24 hours, 48 hours, 72 hours, 96 hours and 7 days after removal of patch
- Number of animals or in vitro replicates:
- 6 animals
- Details on study design:
- Each rabbit was immobilized in a plastic restraining box (Iffa Crédo). The test substance was introduced into the inferior conjunctival sac of the right eye. The left eye served as control. The upper and lower eyelids were held together for several seconds to avoid any loss of test substance.
The animals were restrained for 4 hours, and then replaced in individual cages.
The eyes of 3 rabbits were washed out 4 seconds after instillation, care being taken not to cause injury, and on 3 other animals 30 seconds after the application of the test substance. About 50 ml of the rinsing solution at about 20°C was administered using a plastic jet at moderate pressure.
The control eye was washed out under the same conditions as the treated one.
The excess of liquid was immediately wiped away with a Codex hydrophilic gauze pad.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: Mean Index of Ocular Irritation (M.O.I.)
- Basis:
- mean
- Remarks:
- of 6 animals
- Time point:
- other: 24h
- Score:
- 5.17
- Max. score:
- 110
- Reversibility:
- fully reversible within: 96h
- Irritation parameter:
- other: Mean Index of Ocular Irritation (M.O.I.)
- Basis:
- mean
- Remarks:
- of 6 animals
- Time point:
- other: 48h
- Score:
- 2.67
- Max. score:
- 110
- Reversibility:
- fully reversible within: 96h
- Irritation parameter:
- other: Mean Index of Ocular Irritation (M.O.I.)
- Basis:
- mean
- Remarks:
- of 6 animals
- Time point:
- other: 72h
- Score:
- 0.83
- Max. score:
- 110
- Reversibility:
- fully reversible within: 96h
- Irritation parameter:
- other: Mean Index of Ocular Irritation (M.O.I.)
- Basis:
- mean
- Remarks:
- of 6 animals
- Time point:
- other: 96h
- Score:
- 0
- Max. score:
- 110
- Reversibility:
- fully reversible within: 96h
- Irritant / corrosive response data:
- The substance was found to be slightly irritiating, but not corrosive to rabbit eyes.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The substance was classified as non-irritant to eyes according to EU GHS-criteria.
- Executive summary:
The study was performed 1983, following the EU-testing guideline B.5 as non-GLP-study. 6 New Zealand White rabbits were used in this study. 0.1 ml test item was instilled in the conjunctival sac. Obervations were done applied after one hour, 24, 48 and 72 hours and after 4 and 7 days. The substance was found to be slightly irritating to rabbit eyes.
Valeronitrile is not classified as eye irritant, based on these results.
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