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EC number: 203-781-8 | CAS number: 110-59-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1983
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: the study was performed according to OECD-/EU-testing guidelines, but not under GLP; therefore the study was considered to have Klimisch 2
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Version / remarks:
- Dir. 79/831/EEC, Annex V
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Valeronitrile
- EC Number:
- 203-781-8
- EC Name:
- Valeronitrile
- Cas Number:
- 110-59-8
- Molecular formula:
- C5H9N
- IUPAC Name:
- pentanenitrile
- Details on test material:
- - Physical state: Colourless liquid
- Density: 0.804
- Quantity of test sample: ca. 200 g
- Date of receipt: 7 February 1983
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Centre d'élevage d'IFFA CREDO, 69210 Saint-Germain sur l'Arbresle
- Age at study initiation: 7 weeks old
- Weight at study initiation: 210-220 g males; 160-170 g females
- Housing: in groups à 2 or 5 animals in plastic cages
- Diet (e.g. ad libitum): Souriffarat food ad libitum
- Water (e.g. ad libitum): tap water ad libitum
- Fasting period: 18 hours before treatment
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22°C +/- 1.5°C
- Humidity (%): 55% +/- 15%
- Air changes (per hr): 10 renewals/hr
- Photoperiod (hrs dark / hrs light): not indicated
IN-LIFE DATES: From 09 feb 1983 To 10 march 1983
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: Hydrogel Gum Arabic 10%
- Doses:
- MAIN TEST:
- Dose groups males: 0; 250; 325; 420; 550; 715 mg/kg
- Dose groups females: 0; 650; 715; 785; 865; 950 mg/kg - No. of animals per sex per dose:
- MAIN TEST:
- Ten animals per sex and dose - Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observation, daily. Weighing at D0, D1, D2, D4, D7 and D14.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight. - Statistics:
- Litchfield and Wilcoxon method
Results and discussion
- Preliminary study:
- PRETEST:
- Two animals per sex and dose
- Dose groups: 100; 250; 500; 1000; 1005; 2500; 5000 mg/kg
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 332 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 252 - 437
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 705 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 576 - 863
- Mortality:
- Details are given in the table below.
- Clinical signs:
- other: The following clinical symptoms were observed in one or more animals per dose groups, fifteen minutes or later after treatment: MALES: - 250 mg/kg: depression, ptosis - 325 - 715 mg/kg: depression, ptosis, prostration, piloerection, salivation, hyperexci
- Gross pathology:
- Surviving animals showed no abnormalites at necropsy. Animals that died during the study, all showed a peritoneum aspect edematous, and thickening of the glandular part of the stomach. In some animals, liver and spleen were discolored, and thymic involution greater or lesser degree was observed.
Any other information on results incl. tables
Males
Dose Level (mg/kg) |
No. of deaths |
0 |
0/10 |
250 |
1/10 |
325 |
7/10 |
420 |
7/10 |
550 |
9/10 |
715 |
9/10 |
Females
Dose Level (mg/kg) |
No. of deaths |
0 |
0/10 |
650 |
4/10 |
715 |
6/10 |
785 |
5/10 |
865 |
7/10 |
950 |
7/10 |
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral toxicity LD50 on Sprague-Dawley rats was determined to be 332 mg/kg for males and 705 mg/kg for females.
- Executive summary:
The study was performed in 1983 according to EU-testing guideline B.1, but not in conformity with GLP-principles. The appropriate dose levels were determined in a preliminary test with a reduced number of animals. The main test was conducted with dose groups of 0-715 mg/kg for males and dose groups of 0-950 mg/kg for females. Most of treated animals expressed clinical symptoms, mortality was noted in all dose groups except the control group.
In this study, the acute oral toxicity LD50 on Sprague-Dawley rats was determined to be 332 mg/kg for males and 705 mg/kg for females.
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