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EC number: 203-781-8 | CAS number: 110-59-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1974
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: the study was performed according to OECD-/EU-testing guidelines, but not under GLP; therefore the study was considered to have Klimisch 2
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Version / remarks:
- Dir. 79/831/EEC, Annex V
- Deviations:
- no
- GLP compliance:
- no
Test material
- Reference substance name:
- Valeronitrile
- EC Number:
- 203-781-8
- EC Name:
- Valeronitrile
- Cas Number:
- 110-59-8
- Molecular formula:
- C5H9N
- IUPAC Name:
- pentanenitrile
- Details on test material:
- - Physical state: Colourless liquid
- Density: 0.804
- Quantity of test sample: ca. 200 g
- Date of receipt: 7 February 1983
- pH-value: 9.6 (measured during test)
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: several accredited breeders
- Weight at study initiation: ca. 2.5 kg (+/- 200 g)
- Housing: individual housing on polystyrene cages with perforated polystyrene floor
- Diet (e.g. ad libitum): 150 g per rabbit & day of complete maintenance food (granulés Lapin Entretien "112" UAR, 91360 Villemoisson, Orge)
- Water (e.g. ad libitum): softened and filtered tap water
- Acclimation period: 8 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20°C (+/- 3°C)
- Humidity (%): 30-70%
- Air changes (per hr): 12 times per hour (pre-filtered air 15 µm)
- Photoperiod (hrs dark / hrs light): artificial light for 12 hours
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 0.5 ml as such.
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- Observation 1 hour, 24 hours, 48 hours and 72 hours after removal of patch.
- Number of animals:
- 6 animals
- Details on study design:
- The day before application, the rabiits were carefully clipped on the back and flanks with a fine toothed electric clipper to bare a surface of 14 x 14 cm. 0.5 ml of test substance as such was applied on a Codex hydrophylic sight layer gauze pad of ca. 2.5 cm², previously laid down on the skin to avoid any loss of test substance.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- of 6 animals
- Time point:
- other: 24h
- Score:
- 0.5
- Max. score:
- 4
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- of 6 animals
- Time point:
- other: 48h
- Score:
- 0.5
- Max. score:
- 4
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- of 6 animals
- Time point:
- other: 72h
- Score:
- 0.33
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- of 6 animals
- Time point:
- other: 24h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- of 6 animals
- Time point:
- other: 48h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- of 6 animals
- Time point:
- other: 72h
- Score:
- 0
- Max. score:
- 4
- Irritant / corrosive response data:
- Slight erythema (score 1) were noted in 4 out of 6 animals one hour up to 72 hours after removal of the patch. No oedema were observed. Reversibility was not mentioned in the report.
- Other effects:
- No other findings reported.
Any other information on results incl. tables
The results of PII were summarized below:
Observation |
Mean values over 24, 48 & 72 hours (PII) |
Mean value |
|||||
No.1 |
No.2 |
No.3 |
No.4 |
No.5 |
No.6 |
||
Erythema |
0.66 |
0.33 |
0 |
0 |
0.66 |
1 |
0.43 |
Oedema |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The substance was classified as non-irritant to skin.
- Executive summary:
The study was performed in 1983, following the EU-testing guideline B.4 as non-GLP-study. 6 New Zealand White rabbits were used in this study. 0.5 ml test item was applied undiluted on intact and clipped skin area on the back and flanks by semi-occlusive dressing. Only very slight erythema (score 1) was noted in 4 ot of 6 animals after removal of the patch. No oedema were observed.
Based on these results Valeronitrile was not classified for skin irritation.
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