reaction mass of 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-2H -isothiazol-3-one

Vapour pressure

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Guideline-conform study under GLP without deviations.

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

GLP compliance:

yes (incl. QA statement)

Type of method:

gas saturation method

Temp.:

25 °C

Vapour pressure:

2.8 Pa

Temp.:

35 °C

Vapour pressure:

7.5 Pa

Temp.:

45 °C

Vapour pressure:

17 Pa

Transition / decomposition:

no

Conclusions:

Extrapolated vapour pressure of CIT for 20°C: 1.6 Pa

Reference 2

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2001

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

comparable to guideline study

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

gas saturation method

Key result

Test no.:

#1

Temp.:

25 °C

Vapour pressure:

0.003 Pa

Remarks on result:

not measured/tested

Remarks on result:

not measured/tested

The vapour pressure was determined under Protocol 24P-2000-01 1, via EEC Method A4, OECD Method 104. Details of this study can be found in report RAS 1981004661, Appendix 5.

The vapour pressure of Kathon" 886F lot # 61 10C015 was determined at 20, 25 and 30°C. The vapour pressures with respect to RH-573 and RH-651 at these temperatures are given below:

Partial pressure RH-573 (MI)

0.00162 Pa at 20ºC

0.00314 Pa at 25ºC

0.00550 Pa at 30ºC

 

Partial pressure RH-651(CMIT)

0.108 Pa at 20ºC

0.186 Pa at 25ºC

0.295 Pa at 30ºC

Conclusions:

The vapour pressure at 25OC (298K) of KathonD 886F biocide was determined to be0.00314 Pa with respect to RH-573 and 0.186 Pa with respect to RH-65 1.

Executive summary:

The vapour pressure of a substance is defined as the saturation pressure above a solid or liquid substance. At the thermodynamic equilibrium, the vapour pressure of a pure substance is a function of temperature only and not that of gas flow rate. The SI unit of pressure is the Pascal (Pa).

PROCEDURE

Test substance (5 ml) was placed in two glass bottles connected in series. Six samples were prepared in this way and kept in a thermostatically controlled environment at 30°C, 25°C and 20°C. Nitrogen was passed over the test substance at three different flow rates (two at each flow rate) of approximately 75 mumin, 25 mumin and 12.5 mumin. A series of test bottles with nitrogen flow at the higher rate were used as a control blank. Following an equilibration period, absorbent tubes (orbo-52) were attached to the nitrogen outlets for a fixed period to trap the eluting test substance. At the end of each collection time, the adsorption tubes were removed and the contents of each section extracted with mobile phase (5 ml) by sonifying for 1 hour prior to analysis by HPLC.

The efficiency of the extraction procedure was determined by fortifying adsorption tubes with an aliquot (100 p1) of KathonB 886F biocide standard in mobile phase (ca. 6.7 mglml) and extracting as for the samples above.

PREPARATION OF CALIBRATION STANDARD

A stock calibration solution was prepared by weighing test substance into a volumetric flask and dissolving in and diluting to volume with mobile phase. This solution was serially diluted to obtain calibration solutions in mobile phase of the appropriate concentration.

RESULT

The vapour pressure at 25C (298K) of Kathon 886F biocide was determined to be 0.00314 Pa with respect to RH-573 and 0.186 Pa with respect to RH-65 1.

Reference 3

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: guideline-conform study under GLP without deviations.

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

GLP compliance:

yes (incl. QA statement)

Type of method:

gas saturation method

Temp.:

25 °C

Vapour pressure:

1.6 Pa

Temp.:

20 °C

Vapour pressure:

0.99 Pa

Conclusions:

The vapour pressure of 2-methyl-2H-isothiazol-3-one (MIT) was measured at three temperatures and extrapolated to 20 and 25°C to be 0.99 and 1.6 Pa, respectively, using the Clausius-Clapeyron equation.

Executive summary:

The vapour pressure of 2-methyl-2H-isothiazol-3-one (MIT) was measured by the gas saturation method, at three temperatures (30, 40 and 50 °C) and extrapolated to 20 and 25°C to be 0.99 and 1.6 Pa, respectively, using the Clausius-Clapeyron equation. The test followed the OECD 104 guideline.

Key value for chemical safety assessment

Vapour pressure:

2.2 Pa

at the temperature of:

20 °C

Additional information

CMIT/MIT 3:1