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EC number: 280-349-5 | CAS number: 83261-15-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study according to the OECD guideline 301B.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Isobutyl (S)-2-chloropropionate
- EC Number:
- 280-349-5
- EC Name:
- Isobutyl (S)-2-chloropropionate
- Cas Number:
- 83261-15-8
- Molecular formula:
- C7H13ClO2
- IUPAC Name:
- isobutyl (S)-2-chloropropanoate
- Reference substance name:
- Isobutyl 2-chloropropionate
- EC Number:
- 263-411-6
- EC Name:
- Isobutyl 2-chloropropionate
- Cas Number:
- 62108-67-2
- IUPAC Name:
- isobutyl 2-chloropropanoate
Constituent 1
Constituent 2
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): Aeration tank of WWTP of Mannheim/BasdenWürttemberg (Germany)
- Storage conditions: aerated
- Storage length: 24 hours
- Preparation of inoculum for exposure: A suitable aliquot of the activated sludge suspension was sieved by a finely woven mesh with a mesh size of about 1 mm. After settling the supernatant was discarded and the sludge suspension was filled up with tap water. The sludge of the suspension was adjusted to a concentration of 6.0 g/L dry weight. An aliquot of 7.5 mL was added to the test vessels, to obtain a sludge concentration of 30 mg/L dry substance. Finally the activated sludge suspension in the test vessels was preaerated for about 24 hours at a temperature of 22 ± 2 °C.
- Concentration of sludge: 30 mg/L dry substance - Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- 20 mg/L
- Based on:
- DOC
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- CO2 evolution
- Details on study design:
- TEST CONDITIONS
- Composition of medium: The used mineral medium complies with the test guideline OECD 301B. It was prepared as follows:
Solution A: KH2PO4 : 8.50 g, K2HPO4 : 21.75 g, Na2HPO4 × 2 H2O : 33.40 g, NH4Cl : 0.50 g
The compounds were dissolved in 1000 mL distilled water; the pH value was adjusted to 7.4.
Solution B: CaCl2 × 2 H2O : 36.40 g; the compound was dissolved in 1000 mL distilled water.
Solution C: MgSO4 × 7 H2O : 22.50 g; the compound was dissolved in 1000 mL distilled water.
Solution D: FeCl3 × 6 H2O : 0.25 g; the compound was dissolved in 1000 mL distilled water.
15 mL solution A, 1.5 mL solution B, 1.5 mL solution C and 1.5 mL solution D was used for the preparation of the test assays.
- Test temperature: 22 +/- 2°C
- pH: 7.4 +/- 0.2
- pH adjusted: yes
- Continuous darkness: yes
TEST SYSTEM
- Culturing apparatus: 2 L incubation bottles filled up to a volume of 1.5 L, connected with two serial scrubbing bottles for carbon dioxide absorption
- Number of culture flasks/concentration: 3
- Method used to create aerobic conditions: aeraion with carbn dioxide free air at a flow of 800 ml per hour
- Measuring equipment: TOC-analyzer with auto sampler (Shimadzu TOC-5000A)
- Test performed in closed vessels due to significant volatility of test substance: closed
SAMPLING
- Sampling frequency: after 0, 2, 3, 6, 10, 14, 17, 20, 23, 27, 28 and 29 days
- Sampling method: auto sampler of Shimadzu TOC-5000A
CONTROL AND BLANK SYSTEM
- Inoculum blank: 2 blank controls, 1 inhibition control, 1 reference substance control
Reference substance
- Reference substance:
- aniline
Results and discussion
% Degradation
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 80 - 90
- Sampling time:
- 28 d
- Details on results:
- - Duration of the adaptation phase (days): 4
- Degradation of the test subst. at the end of the ten-day window (% CO2/ThCO2): 70 - 80
- Degradation degree of the reference substance after 14 days (% CO2/ThCO2): 80
- Degradation degree in the inhibition control after 14 days (% CO2/ThCO2): 82
Applicant's summary and conclusion
- Interpretation of results:
- readily biodegradable
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