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Diss Factsheets
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EC number: 206-058-5 | CAS number: 298-12-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Dissociation constant
Administrative data
Link to relevant study record(s)
- Endpoint:
- dissociation constant
- Type of information:
- other: Bibliographic peer reviewed data
- Adequacy of study:
- weight of evidence
- Study period:
- 1985
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- not applicable
- GLP compliance:
- not specified
- Dissociating properties:
- yes
- No.:
- #1
- pKa:
- 3.3
- Temp.:
- 25 °C
- Executive summary:
The acid-base constant of Glyoxylic Acid is 3.3 as reported in Lange´s Handbook of Chemistry.
- Endpoint:
- dissociation constant
- Type of information:
- other: Handbook
- Adequacy of study:
- weight of evidence
- Study period:
- 1989
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- not applicable
- GLP compliance:
- not specified
- Dissociating properties:
- yes
- No.:
- #1
- pKa:
- 4.7
- Temp.:
- 25 °C
- Executive summary:
The acid-base constant of Glyoxylic Acid 50% is 4.7, based on literature data from Ullmann´s encyclopedia.
- Endpoint:
- dissociation constant
- Type of information:
- other: handbook
- Adequacy of study:
- weight of evidence
- Study period:
- 1996
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- not applicable
- GLP compliance:
- not specified
- Dissociating properties:
- yes
- No.:
- #1
- pKa:
- 4.6
- Temp.:
- 25 °C
- Executive summary:
The acide base constant of Glyoxylic Acid is 4.6 as reported in the Merck Index.
- Endpoint:
- dissociation constant
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Justification for type of information:
- QSAR prediction
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Calculation by using SPARC Performance Automated Reasoning in Chemistry (Release w4.5.1529-s4.5.1529; september 2009)
- GLP compliance:
- not specified
- Dissociating properties:
- yes
- No.:
- #1
- pKa:
- 3.12
- Temp.:
- 25 °C
- Executive summary:
By using SPARC Performance Automated Reasoning in Chemistry (V 4.2) the dissociation constant of Glyoxylic Acid was calculated and resulted in pKa of 3.12. For detailed information on the dissociation properties of Glyoxylic Acid see attached file.
Referenceopen allclose all
The acid-base constant of Glyoxylic Acid is 3.3
The acid-base constant of Glyoxylic Acid is 4.6.
Description of key information
The dissociation constant of Glyoxylic Acid 50% is in the range from 3.12-4.7.
Key value for chemical safety assessment
Additional information
Data on the dissociation constant of Glyoxylic Acid 50% is available from handbook literature and values of 3.3, 4.6 and 4.7 are reported. Additionally the dissociation constant of Glyoxylic Acid 50% was calculated as 3.12 by using SPARC Performance Automated Reasoning in Chemistry (V 4.2). The calculated value for the dissociation constant is in line with the reported values from handbook data.
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