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Diss Factsheets
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EC number: 201-180-5 | CAS number: 79-14-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Health surveillance data
Administrative data
- Endpoint:
- health surveillance data
- Type of information:
- other: case report
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Personnal statement
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
Materials and methods
- Study type:
- health record from industry
Test guideline
- Qualifier:
- no guideline required
- GLP compliance:
- no
Test material
- Reference substance name:
- Glycollic acid
- EC Number:
- 201-180-5
- EC Name:
- Glycollic acid
- Cas Number:
- 79-14-1
- Molecular formula:
- C2H4O3
- IUPAC Name:
- 2-hydroxyacetic acid
- Details on test material:
- Glycolic acid
Constituent 1
Method
- Type of population:
- occupational
- Details on study design:
- Health record checks
Results and discussion
- Results:
- Glycolic acid is manufactured in closed systems where reactors and downstream equipment are hard-piped to minimise losses to the environment and to minimise potential exposure to workers. Routine air monitoring in DuPont facilities indicate workplace concentrations to average less than 0.4 mg/m3 (8 hour time weighted average – TWA). Continuous exposure at this level for an entire 8-hour shift would result in a daily intake of less than 0.04 mg/kg bw/day. Glycolic acid is normally packaged and sold in drums or in bulk containers. Air monitoring of drumming and bulk loading operations show typical exposure levels to be less than 0.2 and less than 0.4 mg/m3 respectively. These exposure levels would correspond to a daily intake of <0.02 and <0.04 mg/kg bw/day for exposed workers, assuming continuous exposure at hese levels for an entire 8-hour daily shift.
Current air monitoring data are summarized below:
Loader/Packager:
Time Period Geometric Mean Standard Deviation
7/3/99-5/11/05 0.281 mg/m3 3.461
Field Operator (full shift)
Time period Geometric Mean Standard Deviation
4/16/98 0.127 mg/m3 1.399
Packager (glycolic acid 99% high purity) Geometric Mean Standard Deviation
11/3/99 0.062 mg/m3 2.283
Personal protective equipment for operators consists of wearing a face shield, chemical splash goggles and neoprene gloves when loading glycolic acid. In the glycolic acid production area typically there is one loader per 12 hour shift and one field operator per 12 hour shift. Glycolic Acid is also campaign manufactured – both 70% high purity and Glycolic Acid 99% high purity (in another area on the plant). The operation is straightforward. Glycolic Acid - 85% is unloaded into a reactor, water is added and the material is further purified to the 70% high purity material or is dried in a dryer and packaged out in drums for Glycolic Acid 99% High Purity. One operator is involved per 12 hour shift when Glycolic Acid high purity is being campaign manufactured.
The potential exposure is therefore minimised by physical protective equipment, further limted by the engineering controls and potential exposure is limited to a very small number of individuals involved in the production, loading and packaging processes.
A personnal statement from the Occupational Health Focus Leader at the production plant– Belle Plant, Middle America Cluster, Ohio – indicated that they were unaware of any exposure incidents relating to glycolic acid during a period of 28 years at Belle
Any other information on results incl. tables
No exposure incidents recorded, relating to glycolic acid, during last 28 years. Integrated Health Services Team Leader confirmed: "In the 20 years that I have been employed as a certified occupational health nurse for E.I. DuPont de Nemours I am unaware of any Belle Plant employees having any adverse effects from exposure to glycolic acid".
Applicant's summary and conclusion
- Conclusions:
- Personal correspondence from Occupational Health Focus Leader – Belle Plant, Middle America Cluster, Ohio.
No exposure incidents recorded, relating to glycolic acid, during last 28 years.
Integrated Health Services Team Leader confirmed: ”In the 20 years that I have been employed as a certified occupational health nurse for E.I. DuPont de Nemours I am unaware of any Belle Plant employees having any adverse effects from exposure to glycolic acid”. - Executive summary:
Personal correspondence from Occupational Health Focus Leader – Belle Plant, Middle America Cluster, Ohio. No exposure incidents recorded, relating to glycolic acid, during last 28 years. Integrated Health Services Team Leader confirmed: ”In the 20 years that I have been employed as a certified occupational health nurse for E.I. DuPont de Nemours I am unaware of any Belle Plant employees having any adverse effects from exposure to glycolic acid”.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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