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EC number: 246-278-9 | CAS number: 24468-13-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Title:
- Unnamed
- Year:
- 1 968
- Report date:
- 1968
Materials and methods
- Principles of method if other than guideline:
- Skin irritation was tested using an internal standard method (BASF test). White Vienna rabbits were used. Usually, 2 animals were treated for 1, 5 and 15 minutes and 2 other animals for 20 hours using occlusive conditions. An application site of 2.5 X 2.5 cm was covered with the liquid or powdered and moistened test substance. Differences to OECD TG 404 (exposure time, occlusive dressing)
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-ethylhexyl chloroformate
- EC Number:
- 246-278-9
- EC Name:
- 2-ethylhexyl chloroformate
- Cas Number:
- 24468-13-1
- Molecular formula:
- C9H17ClO2
- IUPAC Name:
- 2-ethylhexyl carbonochloridate
- Details on test material:
- - Name of test material (as cited in study report): 2-Ethylhexylchlorformiat (2-ethylhexylchloroformate)
- Physical state: liquid
- Analytical purity: 99%
- Impurities (identity and concentrations): phosgene and Di-2ethylhexylcarbonate
- Storage condition of test material: dry, cool, in glas containers
- Sability under storage conditions > 2 years
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Gaukler, Offenbach, Germany
- Weight at study initiation: 2.88 kg (F); 2,76 kg (m)
- Housing: single
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
ENVIRONMENTAL CONDITIONS
not reported
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 500 µl - Duration of treatment / exposure:
- Experiment 1: 1, 5, or 15 minutes
Experiment 2: 20 h - Observation period:
- 8 days
- Number of animals:
- 2
- Details on study design:
- TEST SITE
- Area of exposure: An application site of 2.5 X 2.5 cm was covered with the liquid
REMOVAL OF TEST SUBSTANCE
- Washing (if done): none
SCORING SYSTEM:
Similar to the Draize scoring system of OECD TG 404
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Remarks:
- 20 h occlusie
- Time point:
- 24 h
- Score:
- 2
- Max. score:
- 2
- Reversibility:
- not fully reversible within: 8 days
- Remarks on result:
- other: 20 h occlusie
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Remarks:
- 20 h occlusive
- Time point:
- 48 h
- Score:
- 2
- Max. score:
- 2
- Reversibility:
- not fully reversible within: 8 days
- Remarks on result:
- other: 20 h occlusive
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Remarks:
- 20 h occlusive
- Time point:
- 48 h
- Score:
- 3
- Max. score:
- 3
- Reversibility:
- fully reversible within: 8 days
- Remarks on result:
- other: 20 h occlusive
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Remarks:
- 20 h occlusive
- Time point:
- 24 h
- Score:
- 3
- Max. score:
- 3
- Reversibility:
- fully reversible within: 8 days
- Remarks on result:
- other: 20 h occlusive
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Remarks:
- 20 h occlusive
- Time point:
- 24 h
- Score:
- 3
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 8 days
- Remarks on result:
- other: 20 h occlusive
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Remarks:
- 20 h occlusive
- Time point:
- 48 h
- Score:
- 3
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 8 days
- Remarks on result:
- other: 20 h occlusive
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Remarks:
- 20 h occlusive
- Time point:
- 24 h
- Score:
- 2
- Max. score:
- 2
- Reversibility:
- fully reversible within: 8 days
- Remarks on result:
- other: 20 h occlusive
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Remarks:
- 20 h occlusive
- Time point:
- 48 h
- Score:
- 2
- Max. score:
- 2
- Reversibility:
- fully reversible within: 8 days
- Remarks on result:
- other: 20 h occlusive
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Remarks:
- 15 min occlusive
- Time point:
- 24 h
- Score:
- 3
- Max. score:
- 3
- Reversibility:
- fully reversible within:
- Remarks:
- 8 days
- Remarks on result:
- other: 15 min occlusive
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Remarks:
- 15 min occlusive
- Time point:
- 48 h
- Score:
- 3
- Max. score:
- 3
- Reversibility:
- fully reversible within: 8 days
- Remarks on result:
- other: 15 min occlusive
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Remarks:
- 15 min occlusive
- Time point:
- 24 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- not specified
- Remarks on result:
- other: 15 min occlusive
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Remarks:
- 15 min occlusive
- Time point:
- 48 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- not specified
- Remarks on result:
- other: 15 min occlusive
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Remarks:
- 15 min occlusive
- Time point:
- 24 h
- Score:
- 3
- Max. score:
- 3
- Reversibility:
- fully reversible within: 8 days
- Remarks on result:
- other: 15 min occlusive
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Remarks:
- 15 min occlusive
- Time point:
- 48 h
- Score:
- 3
- Max. score:
- 3
- Reversibility:
- fully reversible within: 8 days
- Remarks on result:
- other: 15 min occlusive
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Remarks:
- 15 min occlusive
- Time point:
- 24 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- not specified
- Remarks on result:
- other: 15 min occlusive
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Remarks:
- 15 min occlusive
- Time point:
- 48 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- not specified
- Remarks on result:
- other: 15 min occlusive
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- 20 h occlusive
- Time point:
- 72 h
- Remarks on result:
- not measured/tested
- Remarks:
- 20 h occlusive
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- 20 h occlusive
- Time point:
- 72 h
- Remarks on result:
- not measured/tested
- Remarks:
- 20 h occlusive
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- 15 min occlusive
- Time point:
- 72 h
- Remarks on result:
- not measured/tested
- Remarks:
- 15 min occlusive
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- 15 min occlusive
- Time point:
- 72 h
- Remarks on result:
- not measured/tested
- Remarks:
- 15 min occlusive
- Irritant / corrosive response data:
- sever irritant (for detailed results see remarks on results below)
Any other information on results incl. tables
Descriptive scores of the raw data have been converted to Draize numerical scores.
Exposure |
20h |
|
|
|
Animal |
Reading |
Erythema |
Edema |
Comment |
1 |
24 h |
2 |
3 |
|
1 |
48 h |
2 |
3 |
|
1 |
8 d |
2 |
0 |
moderate to strong eschar formation |
mean |
24-48 h |
2 |
3 |
|
2 |
24 h |
3 |
2 |
|
2 |
48 h |
3 |
2 |
|
2 |
8 d |
2 |
0 |
moderate to strong eschar formation |
mean |
24-48 h |
3 |
2 |
|
|
|
|
|
|
Exposure |
15 min |
|
|
|
Animal |
Reading |
Erythema |
Edema |
Comment |
1 |
24 h |
3 |
0 |
|
1 |
48 h |
3 |
0 |
|
1 |
8 d |
0 |
0 |
moderate to strong eschar formation |
mean |
24-48 h |
3 |
0 |
|
2 |
24 h |
3 |
0 |
|
2 |
48 h |
3 |
0 |
|
2 |
8 d |
0 |
0 |
moderate to strong eschar formation |
mean |
24-48 h |
3 |
0 |
|
|
|
|
|
|
Exposure |
5 min |
|
|
|
Animal |
Reading |
Erythema |
Edema |
Comment |
1 |
24 h |
3 |
0 |
|
1 |
48 h |
3 |
0 |
|
1 |
8 d |
0 |
0 |
moderate to strong eschar formation |
mean |
24-48 h |
3 |
0 |
|
2 |
24 h |
3 |
0 |
|
2 |
48 h |
3 |
0 |
|
2 |
8 d |
0 |
0 |
moderate to strong eschar formation |
mean |
24-48 h |
3 |
0 |
|
|
|
|
|
|
Exposure |
1 min |
|
|
|
Animal |
Reading |
Erythema |
Edema |
Comment |
1 |
24 h |
3 |
0 |
|
1 |
48 h |
3 |
0 |
|
1 |
8 d |
0 |
0 |
moderate to strong eschar formation |
mean |
24-48 h |
3 |
0 |
|
2 |
24 h |
3 |
0 |
|
2 |
48 h |
3 |
0 |
|
2 |
8 d |
0 |
0 |
moderate to strong eschar formation |
mean |
24-48 h |
3 |
0 |
|
Applicant's summary and conclusion
- Conclusions:
- 2-Ethylhexylchloroformates is irritating to the skin.
- Executive summary:
Undiluted 2-ethylhexanoylchloride (0.5 mL) was applied onto the skin of shaved White Vienna rabbits. Two animals were treated for 1, 5 and 15 minutes and 2 other animals for 20 hours using occlusive conditions. Erythema (24 h score 3/4) was observed following a 15-min occlusive exposure. Erythema (up to score 3) and edema (up to score 3) were observed after a 20 h exposure. For 20 h exposure, erythema (score 2) was still visible 8 days after treatment. The overall primary irritation score (intact skin) was 5.0/8.0 (20 h exposure) and 3/8.0 (15 min exposure), which was consistent with a rating of moderately irritating in both cases.
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