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EC number: 246-278-9 | CAS number: 24468-13-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- Limited documentation (e.g. only mean body weights are reported) and pre-GLP/pre-OECD TG.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- Limited documentation (e.g. only mean body weights are reported), pre-GLP, pre-OECD TG.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2-ethylhexyl chloroformate
- EC Number:
- 246-278-9
- EC Name:
- 2-ethylhexyl chloroformate
- Cas Number:
- 24468-13-1
- Molecular formula:
- C9H17ClO2
- IUPAC Name:
- 2-ethylhexyl carbonochloridate
- Details on test material:
- - Name of test material (as cited in study report): 2-Ethylhexylchlorformiat (2-ethylhexylchloroformate)
- Physical state: liquid
- Analytical purity: 99%
- Impurities (identity and concentrations): phosgene and Di-2ethylhexylcarbonate
- Storage condition of test material: dry, cool, in glas containers
- Sability under storage conditions > 2 years
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hageman + Wiga, Ottobrunn (Germany)
- Weight at study initiation: 211 g (male); 175 (female)
- Fasting period before study: 15-20 h
- Diet (e.g. ad libitum): Herilan MRH-Haltung; H. Eggemann KG
ENVIRONMENTAL CONDITIONS
Not reported
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 4.3; 9.3; 20.0; 52.2; 92.8; 100 %
MAXIMUM DOSE VOLUME APPLIED: 2ml/animal - Doses:
- 215; 464, 1000, 2610, 4640, 5000, 6810, 8250 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Weighing was performed at day of applicaion, 7 days after application and 13 days after application (on day before termination of the study). Observation of clinical signs was several times on the day of administration and once daily afterwards with the except on weekends and on holidays.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, - Statistics:
- The LC50 value was analyzed according to the Probit analysis of Finney (1971) using a computer program.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 5 420 mg/kg bw
- 95% CL:
- 4 913 - 6 050
- Mortality:
- No animal died at doses up to 2610 mg/kg bw. All animals died at the highest dose group. Most deaths occurred within 2 days after dosing, and all occured within 7 days. See table below for dose specific data.
- Clinical signs:
- other: Minor symptoms were noted in the animal groups at 215, 464, and 1000 mg/kg bw. In animals 2610, 4640, and 5000 mg/kg bw signs of toxicity included apathy, dyspnea, staggering, tremor, ruffled fur, exophthalmus, and poor general state. Animals at 6810 an
- Gross pathology:
- Animals that died:
heart: congestion; lung: extended, pulmonary emphysema;
stomach: cases of gastric corrosion (leather-like mucosa);
liver: cases of grayish increased lobular periphery.
Sacrificed animals:
No findings in animals at 215 - 2610 mg/kg bw.
In animals at 4640 - 6810 mg/kg bw wall of forestomach thickened; some cases of diverticle formation.
Any other information on results incl. tables
Mortality after 14 days
Dose (mg/kg) |
Males dead/exposed |
Female dead/exposed |
215 |
0/5 |
0/5 |
464 |
0/5 |
0/5 |
1000 |
0/5 |
0/5 |
2610 |
0/5 |
0/5 |
4640 |
1/5 |
1/5 |
5000 |
1/5 |
2/5 |
6810 |
4/5 |
5/5 |
8250 |
5/5 |
5/5 |
Applicant's summary and conclusion
- Conclusions:
- 2 -ethylhexylchloroformate is of low toxicity after oral uptake.
- Executive summary:
The study is according to OECD 401 with acceptable restrictions mostly due to limited documentation (e.g. only mean body weights are reported), pre-GLP, pre-OECD TG. Male and female Sprague Dawley rats were dosed 215; 464, 1000, 2610, 4640, 5000, 6810, 8250 mg/kg 2 -ethylhexylchloroformate. No animal died at doses up to 2610 mg/kg bw. All animals died at the highest dose group. Most deaths occurred within 2 days after dosing, and all occured within 7 days. The oral LD50 value is 5420 mg/kg bw.
Minor symptoms were noted in the animal groups up to1000 mg/kg bw. At higer doses poor general state, staggering, tremor, ruffled fur, exophthalmus, dyspnea and apathy up to loss of cornea reflexes were observd.
Conclusion: 2-ethylhexylchloroformate is of low toxicity after oral uptake.
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